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mTOR inhibitor-1

Cat. No. M10271
mTOR inhibitor-1 Structure
Synonym:

mTOR-IN-1

Size Price Availability Quantity
2mg USD 100  USD100 In stock
5mg USD 220  USD220 In stock
10mg USD 400  USD400 In stock
25mg USD 800  USD800 In stock
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Quality Control
Biological Activity

mTOR inhibitor-1 is a potential ATP-competitive inhibitor of mTOR which could inhibit cell growth and proliferation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 363.21
Formula C16H15BrN2O3
CAS Number 468747-17-3
Purity >99%
Solubility DMSO 72 mg/mL
Storage at -20°C
References

[1] Jiyuan Liu, et al. Mol Pharm. In Silico Discovery of a Small Molecule Suppressing Lung Carcinoma A549 Cells Proliferation and Inducing Autophagy via mTOR Pathway Inhibition

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Keywords: mTOR inhibitor-1, mTOR-IN-1 supplier, mTOR, inhibitors

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