| Cat.No. | Name | Information |
|---|---|---|
| M1768 | Rapamycin | Rapamycin (Sirolimus,Rapamune)is an inhibitor of mTOR.The mammalian target of rapamycin (mTOR) is a kinase responsible for mitogen-induced cell proliferation/survival signaling. |
| M3722 | Temsirolimus | Temsirolimus (WAY-130779, CCI-779) is a specific mTOR inhibitor with IC50 of 1.76 μM. |
| M1666 | AZD8055 | AZD8055 is a novel ATP-competitive inhibitor of mTOR kinase (both complexes mTORC1 and mTORC2) with an IC50 of 0.8 nM. |
| M2151 | INK128 (Sapanisertib) | INK128 (Sapanisertib; MLN0128) is a potent and selective dual TORC1/2 inhibitor with IC50 of 1 nM. |
| M1709 | Everolimus | Everolimus (RAD001) also known as SDZ-RAD and Certican is an mTOR inhibitor with IC50 of 0.63 nM. |
| M9050 | MHY1485 | MHY1485 is an mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes. |
| M2276 | Torin 1 | Torin 1 is a potent and selective inhibitor of mTOR with IC50 of 2 and 10 nM for mTORC1 and mTORC2, respectively. Torin 1 induces cellular autophagy. |
| M10032 | L-Leucine | L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway. |
| M1981 | Torkinib (PP242) | Torkinib (PP242) is a selective, ATP-competitive mTORC1/mTORC2 inhibitor with IC50 of 8 nM. |
| M7074 | OAC-2 | OAC-2 is a oct4 activator; enhances iPSC reprogramming efficiency. |
| M6226 | GNE-477 | GNE-477 is a potent and efficacious dual PI3K (IC50=4 nM)/mTOR(Ki=21 nM) inhibitor. |
| M6130 | Zotarolimus | Zotarolimus (ABT-578) is an analogue of rapamycin, and inhibits FKBP-12 binding with IC50 of 2.8 nM. |
| M4961 | CB72666407 | Pyrimidine substituted purine compounds as kinase (S) inhibitors. |
| M4934 | Onatasertib (CC-223) | Onatasertib (CC-223) is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3Kα (IC50=4 μM). |
| M4852 | LY303511 | LY303511 is a structural analogue of LY294002, which does not inhibit PI3K, increased homotypic GJIC. |
| M4001 | Aloe-emodin | Aloe-emodin (AE), a hydroxyanthraquinone present in Aloe vera leaves, has a specific in vitro and in vivo antineuroectodermal tumor activity. Aloe-emodin can bind with mTORC2 and inhibit its kinase activity. |
| M3899 | Salidroside | Salidroside is a phenylpropanoid extracted from Rhodiola rosea that exhibits a protective effect against iron death by activating AMPK. It is also a prolyl endopeptidase inhibitor. |
| M3556 | WYE-125132 | WYE-125132 is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR. |
| M2299 | Vistusertib | Vistusertib (AZD2014) is a novel dual mTORC1 and mTORC2 inhibitor with potential antineoplastic activity. |
| M2118 | XL388 | XL388 is a novel, highly potent, ATP-competitive and orally bioavailable mTOR inhibitor. |
| M2099 | OSI-027 | OSI-027 is an orally bioavailable, potent and selective inhibitor of mTORC1 and mTORC2 with IC50 values of 22 nM and 65 nM, respectively. |
| M2094 | GDC-0349 | GDC-0349 is a potent and selective, ATP-competitive mTOR inhibitor. |
| M2022 | Torin 2 | Torin 2 is a potent and selective mTOR inhibitor with IC50 of 2.1 nM. Torin 2 also inhibits DNA-PK with an IC50 of 0.5 nM in the cell free assay. Torin 2 can suppress both mTORC1 and mTORC2. |
| M1981 | Torkinib (PP242) | Torkinib (PP242) is a selective, ATP-competitive mTORC1/mTORC2 inhibitor with IC50 of 8 nM. |
| M1852 | WAY-600 | WAY-600 is a selective single digit nanomolar ATP-competitive mTOR inhibitor with an IC50 of about 9 nM. |
| M1760 | Palomid 529 | Palomid 529 (P529) is a novel potent PI3K/Akt/mTOR inhibitor and shows a potent antiproliferative activity in the NCI-60 cell lines panel, with growth inhibitory 50 (GI50) <35 μM. |
| M1756 | WYE-687 | WYE-687 is a novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin (mTOR) with an IC50 of 7 nM. |
| M1755 | WYE-354 | WYE-354 is a cell-permeable pyrazolopyrimidine compound that acts as a potent and ATP-competitive mTOR inhibitor (IC50 = 5 nM with S6K as the substrate and 100 µM ATP). |
| M1731 | KU-0063794 | KU-0063794 is a potent and selective mTOR inhibitor with IC50 values of approximately 10 nM for mTORC1 and mTORC2. |
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