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L-Leucine

Cat. No. M10032
L-Leucine Structure
Size Price Availability Quantity
1g USD 20  USD20 In stock
5g USD 25  USD25 In stock
50g USD 60  USD60 In stock
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Biological Activity

L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway. Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation. L-Leucine increases intracellular HIF-1α levels and activates the HIF-1α signaling pathway, and these two effects are mediated by the mTOR signaling pathway. This process results in Ngn3 repression and, consequently, decreases β-cell differentiation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 131.17
Formula C6H13NO2
CAS Number 61-90-5
Purity >99%
Solubility Water 10 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Latif Rachdi, et al. Diabetes. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway

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