mTOR Mammalian Target Of Rapamycin

Cat.No.	Name	Information
M1768	Rapamycin	Rapamycin (Sirolimus,Rapamune)is an inhibitor of mTOR.The mammalian target of rapamycin (mTOR) is a kinase responsible for mitogen-induced cell proliferation/survival signaling.
M3722	Temsirolimus	Temsirolimus (WAY-130779, CCI-779) is a specific mTOR inhibitor with IC50 of 1.76 μM.
M1666	AZD8055	AZD8055 is a novel ATP-competitive inhibitor of mTOR kinase (both complexes mTORC1 and mTORC2) with an IC50 of 0.8 nM.
M2151	INK128 (Sapanisertib)	INK128 (Sapanisertib; MLN0128) is a potent and selective dual TORC1/2 inhibitor with IC50 of 1 nM.
M1709	Everolimus	Everolimus (RAD001) also known as SDZ-RAD and Certican is an mTOR inhibitor with IC50 of 0.63 nM.
M9050	MHY1485	MHY1485 is an mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.
M2276	Torin 1	Torin 1 is a potent and selective inhibitor of mTOR with IC50 of 2 and 10 nM for mTORC1 and mTORC2, respectively. Torin 1 induces cellular autophagy.
M10032	L-Leucine	L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
M1981	Torkinib (PP242)	Torkinib (PP242) is a selective, ATP-competitive mTORC1/mTORC2 inhibitor with IC50 of 8 nM.
M1703	Deforolimus	Deforolimus (also known as AP23573 and MK-8669) is an investigational targeted and small-molecule mTOR inhibitor. *The compound is unstable in solutions, freshly prepared is recommended
M57072	RMC-4627	RMC-4627 is a selective mTORC1 inhibitor that activates 4EBP1 and inhibits tumor growth.
M57071	RMC-4529	RMC-4529 has an IC50 value of 1.0 nM against p-4E-BP1-(T37/46) in mTOR kinase cellular assay.
M57070	WYE-687 dihydrochloride	WYE-687 dihydrochloride is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM.
M50430	Thioether-cyclized helix B peptide, CHBP	Thioether-cyclized helix B peptide, CHBP can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2.
M43385	mTOR inhibitor-11	mTOR inhibitor-11 is a brain-penetrant mTOR inhibitor (IC50: 21 nM for pS6).
M43384	mTOR inhibitor-12	mTOR inhibitor-12 is a selective brain penetrant mTOR inhibitor without genotoxicity risk.
M43383	Royleanone	Royleanone, a diterpenoid isolated from plants, inhibits the proliferation of cancer cells by inducing cell cycle arrest and mitochondria-mediated apoptosis.
M39838	Zederone	Zederone, a germacrane-type sesquiterpene, has potently cytotoxic against human white blood cancer cells and human prostate cancer cells. Zederone significantly inhibits the proliferation and downregulates the protein expressions of mTOR, and phosphorylated p70 S6 kinase (p-p70s6K) in SKOV3 cells.
M29786	MHY-1685	MHY-1685, a novel mammalian target of rapamycin (mTOR) inhibitor, provides opportunities to improve hCSC-based myocardial regeneration.
M29584	RMC-6272	RMC-6272 (RM-006) is a bi-steric mTORC1-selective inhibitor. RMC-6272 exhibits potent and selective (> 10-fold) inhibition of mTORC1 over mTORC2. RMC-6272 shows improved inhibition of mTORC1 in comparison to Rapamycin, and induces more cell death in TSC2 null tumors.
M29096	eCF309	eCF309 is a potent and highly selective mTOR inhibitor with remarkably low off-target activities (IC50 = 10-15 nM, both in vitro and in cells).
M29030	PQR626	PQR626, a rapamycin derivative, is a potent, selective, orally active, and brain-penetrant mTOR inhibitor, with an IC50 and Ki of 5 nM and 3.6 nM, respectively. PQR626 can be can be used for the research of neurological disorders.
M27987	CC214-2	CC214-2 is an oral active and selective mTOR kinase inhibitor. CC214-2 targets to both of mTORC1 (pS6) and mTORC2 (pAktS473). CC214-2 induces autophagy, which is a potential target for host-directed therapy (HDT) in tuberculosis. CC214-2 exhibits synergistic bactericidal and sterilizing activity agasinst tuberculosis (TB), and shortens the treatment duration. CC214-2 also inhibits Rapamycin-resistant signaling and the growth of glioblastomas in vitro and in vivo.
M27795	AZD3147	AZD3147 is a potent, orally active, selective dual inhibitor of mTORC1 and mTORC2 with an IC50 value of 1.5 nM. AZD3147 also has a selective effect on PI3K.
M27779	PP30	PP30, a TORKinib, is a potent, selective, and ATP-competitive inhibitor of mTOR with an IC50 of 80 nM.
M21167	RMC-5552	The selective mTORC1 complex inhibitor RMC-4529 is a bidentate inhibitor that has a rapamycin-derived, FKBP12-induced heterologous mTOR inhibitor covalently linked to an active-site (orthologous) inhibitor.
M14843	PQR620	PQR620 is an orally bioavailable and selective brain penetrant inhibitor of mTORC1/2.

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mTOR Mammalian Target Of Rapamycin

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