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Zederone

Cat. No. M39838

All AbMole products are for research use only, cannot be used for human consumption.

Zederone Structure

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Quality Control & Documentation
Biological Activity

Zederone, a germacrane-type sesquiterpene, has potently cytotoxic against human white blood cancer cells and human prostate cancer cells. Zederone significantly inhibits the proliferation and downregulates the protein expressions of mTOR, and phosphorylated p70 S6 kinase (p-p70s6K) in SKOV3 cells.

Chemical Information
Molecular Weight 246.3
Formula C15H18O3
CAS Number 7727-79-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Sudarshana Borah et al. CNS Neurol Disord Drug Targets. Zederone Improves the Fecal Microbial Profile in Dementia Induced Rat Model: A First Report

[2] Zhilei Zhang et al. J BUON. A study of zederone for the inhibition on ovarian cancer cell proliferation through mTOR/p70s6K signalling pathway

[3] Prapapan Pimkaew et al. Int J Toxicol. Zederone, a sesquiterpene from Curcuma elata Roxb, is hepatotoxic in mice

[4] Prapapan Pimkaew et al. Toxicol In Vitro. Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system

[5] H Hikino et al. Chem Pharm Bull (Tokyo). Structure of zederone

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Keywords: Zederone supplier, mTOR, inhibitors, activators

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