PQR620

Cat. No. M14843

All AbMole products are for research use only, cannot be used for human consumption.

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.

Quality Control & Documentation

Purity: >99%
COA
MSDS

Product Information

Biological Activity

PQR620 is an orally bioavailable and selective brain penetrant inhibitor of mTORC1/2.

Chemical Information

Molecular Weight	445.47
CAS Number	1927857-56-4
Solubility (25°C)	DMSO 6.4 mg/mL
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

References

[1] Jian-Hua Zha, et al. The Anti-Non-Small Cell Lung Cancer Cell Activity by a mTOR Kinase Inhibitor PQR620

[2] Elisabeth Singer, et al. Brain-penetrant PQR620 mTOR and PQR530 PI3K/mTOR inhibitor reduce huntingtin levels in cell models of HD

[3] Chiara Tarantelli, et al. The Novel TORC1/2 Kinase Inhibitor PQR620 Has Anti-Tumor Activity in Lymphomas as a Single Agent and in Combination with Venetoclax

[4] Denise Rageot, et al. Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders

[5] Claudia Brandt, et al. The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy

Related mTOR Products
RMC-4627 RMC-4627 is a selective mTORC1 inhibitor that activates 4EBP1 and inhibits tumor growth.
RMC-4529 RMC-4529 has an IC50 value of 1.0 nM against p-4E-BP1-(T37/46) in mTOR kinase cellular assay.
WYE-687 dihydrochloride WYE-687 dihydrochloride is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM.
Rapamycin-d3 Rapamycin-d3
L-Leucine-d10 L-Leucine-d10

Catalog

Keywords: PQR620 supplier, mTOR, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.

By Signaling Pathways

By Product Type

Signaling Pathways

PQR620

Price and Availability

Quality Control & Documentation

Biological Activity

Chemical Information

References

Get to Know Us

Customer Support

Resources

Contact Us