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NV-5138

Cat. No. M11005
NV-5138 Structure
Size Price Availability Quantity
5mg USD 250  USD250 In stock
10mg USD 380  USD380 In stock
25mg USD 820  USD820 In stock
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Quality Control & Documentation
Biological Activity

NV-5138, a leucine analogue, is the first selective, orally active intra-brain mTORC1 agonist in combination with Sestrin2. NV-5138 can be used in biological studies of antidepressants.

Chemical Information
Molecular Weight 181.18
Formula C7H13F2NO2
CAS Number 2095886-80-7
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ioline D Henter, et al. CNS Drugs. Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status

[2] Yuto Hasegawa, et al. J Clin Invest. NV-5138 as a fast-acting antidepressant via direct activation of mTORC1 signaling

[3] Taro Kato, et al. J Clin Invest. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation

[4] Shomit Sengupta, et al. Sci Rep. Discovery of NV-5138, the first selective Brain mTORC1 activator

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Keywords: NV-5138 supplier, mTOR, inhibitors, activators

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