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NV-5138

Cat. No. M11005
NV-5138 Structure
Size Price Availability Quantity
5mg USD 250  USD250 In stock
10mg USD 380  USD380 In stock
25mg USD 820  USD820 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

NV-5138, a leucine analogue, is the first selective, orally active intra-brain mTORC1 agonist in combination with Sestrin2. NV-5138 can be used in biological studies of antidepressants.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 181.18
Formula C7H13F2NO2
CAS Number 2095886-80-7
Purity >98%
Solubility DMSO ≥ 100 mg/mL
Storage at -20°C
References

[1] Ioline D Henter, et al. CNS Drugs. Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status

[2] Yuto Hasegawa, et al. J Clin Invest. NV-5138 as a fast-acting antidepressant via direct activation of mTORC1 signaling

[3] Taro Kato, et al. J Clin Invest. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation

[4] Shomit Sengupta, et al. Sci Rep. Discovery of NV-5138, the first selective Brain mTORC1 activator

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