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NV-5138

Cat. No. M11005

All AbMole products are for research use only, cannot be used for human consumption.

NV-5138 Structure
Size Price Availability Quantity
5mg USD 250  USD250 In stock
10mg USD 380  USD380 In stock
25mg USD 820  USD820 In stock
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Quality Control & Documentation
Biological Activity

NV-5138, a leucine analogue, is the first selective, orally active intra-brain mTORC1 agonist in combination with Sestrin2. NV-5138 can be used in biological studies of antidepressants.

Chemical Information
Molecular Weight 181.18
Formula C7H13F2NO2
CAS Number 2095886-80-7
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ioline D Henter, et al. CNS Drugs. Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status

[2] Yuto Hasegawa, et al. J Clin Invest. NV-5138 as a fast-acting antidepressant via direct activation of mTORC1 signaling

[3] Taro Kato, et al. J Clin Invest. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation

[4] Shomit Sengupta, et al. Sci Rep. Discovery of NV-5138, the first selective Brain mTORC1 activator

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Keywords: NV-5138 supplier, mTOR, inhibitors, activators

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