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RMC-5552

Cat. No. M21167

All AbMole products are for research use only, cannot be used for human consumption.

RMC-5552  Structure

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Quality Control & Documentation
Biological Activity

The selective mTORC1 complex inhibitor RMC-4529 is a bidentate inhibitor that has a rapamycin-derived, FKBP12-induced heterologous mTOR inhibitor covalently linked to an active-site (orthologous) inhibitor.

Chemical Information
Molecular Weight 1778.13
Formula C93H136N10O24
CAS Number 2382768-62-7
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] G Leslie Burnett, et al. J Med Chem. Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors

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RMC-4627 is a selective mTORC1 inhibitor that activates 4EBP1 and inhibits tumor growth.

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RMC-4529 has an IC50 value of 1.0 nM against p-4E-BP1-(T37/46) in mTOR kinase cellular assay.

WYE-687 dihydrochloride 

WYE-687 dihydrochloride is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM.

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  Catalog
Abmole Inhibitor Catalog




Keywords: RMC-5552 supplier, mTOR, inhibitors, activators

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