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mTOR inhibitor-3

Cat. No. M14842

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mTOR inhibitor-3 Structure
Size Price Availability
5mg USD 200  USD200 4-7 Days
10mg USD 280  USD280 4-7 Days
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Quality Control & Documentation
Biological Activity

mTOR inhibitor-3 is a remarkably selective mTOR inhibitor with a Ki of 1.5 nM. mTOR inhibitor-3 suppresses mTORC1 and mTORC2 in cellular and in vivo pharmacokinetic (PK)/pharmacodynamic (PD) experiments.

Chemical Information
Molecular Weight 474.56
CAS Number 1207358-59-5
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Shucheng Chen, et al. Autophagy inhibitor potentiates the antitumor efficacy of apatinib in uterine sarcoma by stimulating PI3K/Akt/mTOR pathway

[2] Shaohong Fang, et al. Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway

[3] Dan Li, et al. Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress

[4] Ding-Mei Zhang, et al. TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury

[5] Wenyu Zhao, et al. SIRT3 Protects Against Acute Kidney Injury via AMPK/mTOR-Regulated Autophagy

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Keywords: mTOR inhibitor-3 supplier, mTOR, inhibitors, activators

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