| Cat.No. | Name | Information |
|---|---|---|
| M1934 | Tacrolimus (FK506) | Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. *The compound is unstable in solutions, freshly prepared is recommended |
| M3380 | Pitavastatin Calcium | Pitavastatin Calcium is a new type of statin. |
| M3497 | Simvastatin (MK 733) | Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. Simvastatin inhibits exosome release. Prior to use in cell assays, Simvastatin needs to be activated by NaOH in EtOH treatment. |
| M2510 | Chloroquine diphosphate | Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent. |
| M9559 | Chloroquine | Chloroquine is an inhibitor of autophagy and Toll-like receptors (TLRs). Chloroquine can effectively inhibit SARS-COV-2 infection (EC50=1.13 μM). Chloroquine is an anti-inflammatory widely used in malaria and rheumatoid arthritis. |
| M9765 | Dimethyl itaconate | Dimethyl itaconate may be used in functionalization of isotactic poly(propylene). |
| M9059 | TBHQ | TBHQ is an aromatic organic compound, as a selective inducer of Nrf2 in a preclinical model of ICH. TBHQ (tert-Butylhydroquinone) is also an ERK activator. |
| M2049 | Metformin hydrochloride | Metformin HCl is a biguanide inhibitor that reduces blood glucose mainly by inhibiting hepatic glycogen production (hepatic gluconeogenesis), while Metformin is a CD47 inhibitor in vitro. |
| M9069 | AS1842856 | AS1842856 is a cell-permeable Foxo1 inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. |
| M5961 | Silibinin | Silibinin, the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury. |
| M55911 | KAN0438757 | KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM. |
| M55910 | Metofenazate | Metofenazate is a selective calmodulin inhibitor. |
| M54633 | FDW028 | FDW028 is a potent and highly selective FUT8 inhibitor. FDW028 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the CMA pathway. |
| M53364 | Calmodulin-Dependent Protein Kinase II (290-309) | Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II. |
| M53363 | Microcolin H | Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. |
| M53362 | Forigerimod | Forigerimod (IPP-201101) is a CD4 T-cell modulator. |
| M45399 | CUR5g | CUR5g is a potent autophagy inhibitor that selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion. CUR5g also prevents STX17 from being recruited to autophagosomes through a UVRAG-dependent mechanism, resulting in the inability of autophagosomes to fuse with lysosomes. In addition, CUR5g enhances the in vitro and in vivo anticancer effects of cisplatin in A549 cells. |
| M45008 | Sotetsuflavone | Sotetsuflavone is a flavonoid that can be isolated from Cycas revolute. |
| M44869 | Guaiol | Guaiol is a sesquiterpene alcohol that has been found in several traditional Chinese medicinal plants and has antiproliferative, pro-autophagic, insect repellent, and insecticidal biological activities. |
| M41414 | HDAC-IN-62 | HDAC-IN-62 a HDAC inhibitor, with IC50s of 0.78, 1.0, 1.2? μM for HDAC6/8/11 respectively. |
| M41413 | HDAC10-IN-2 hydrochloride | HDAC10-IN-2 hydrochloride is a potent and highly selective HDAC10 inhibitor, with an IC50 of 20 nM. |
| M41385 | AMDE-1 | AMDE-1 is a potent autophagy inducer. |
| M41384 | H1k | H1k, a Eudistomin Y derivative, is a lysosome-targeted antiproliferation agent. |
| M41383 | VISTA-IN-2 | VISTA-IN-2 is an inhibitor of V-domain Ig suppressor of T-cell activation (VISTA). |
| M41382 | Lucanthone hydrochloride | Lucanthone hydrochloride is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1). |
| M41381 | NDBM | NDBM is a probe and binds to tumor-specific Pim-1 kinase, releases strong fluorescence, and produces cytotoxicity, thus achieving cell screening and killing effects. |
| M41314 | MTP | MTP is a PKM2 inhibitor. |
| M38862 | Zingiberene | Zingiberene (α-Zingiberene) is a monocyclic sesquiterpene which is the predominant constituent of ginger with oil content (Zingiber officinale). Neuroprotective potential. Zingiberene triggers autophagy. Anticancer activity. |
| M38861 | Thonningianin B | Thonningianin B is an antioxidant and an autophagy enhancer. |
| M38860 | Calcineurin substrate | Calcineurin substrate is a peptide from the regulatory RII subunit of cAMP-dependent protein kinase. It can be used in the calcineurin activity assay. |
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