| Cat.No. | Name | Information |
|---|---|---|
| M1934 | Tacrolimus (FK506) | Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. *The compound is unstable in solutions, freshly prepared is recommended |
| M3380 | Pitavastatin Calcium | Pitavastatin Calcium is a new type of statin. |
| M3497 | Simvastatin (MK 733) | Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. Simvastatin inhibits exosome release. Prior to use in cell assays, Simvastatin needs to be activated by NaOH in EtOH treatment. |
| M2510 | Chloroquine diphosphate | Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent. |
| M9559 | Chloroquine | Chloroquine is an inhibitor of autophagy and Toll-like receptors (TLRs). Chloroquine can effectively inhibit SARS-COV-2 infection (EC50=1.13 μM). Chloroquine is an anti-inflammatory widely used in malaria and rheumatoid arthritis. |
| M9765 | Dimethyl itaconate | Dimethyl itaconate may be used in functionalization of isotactic poly(propylene). |
| M9059 | TBHQ | TBHQ is an aromatic organic compound, as a selective inducer of Nrf2 in a preclinical model of ICH. TBHQ (tert-Butylhydroquinone) is also an ERK activator. |
| M2049 | Metformin hydrochloride | Metformin HCl is a biguanide inhibitor that reduces blood glucose mainly by inhibiting hepatic glycogen production (hepatic gluconeogenesis), while Metformin is a CD47 inhibitor in vitro. |
| M9069 | AS1842856 | AS1842856 is a cell-permeable Foxo1 inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. |
| M5961 | Silibinin | Silibinin, the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury. |
| M5954 | Selenomethionine | Selenomethionine is a naturally occurring amino acid containing selenium, is a common natural food source of selenium. |
| M5911 | Pyriproxyfen | Pyriproxyfen is a juvenile hormone analog, preventing larvae from developing into adulthood and thus rendering them unable to reproduce. Pyriproxyfen is a pyridine-based pesticide which is found to be effective against a variety of arthropoda. |
| M5824 | Nortriptyline hydrochloride | Nortriptyline hydrochloride is a tricyclic antidepressant used to relieve the symptoms of depression. |
| M5714 | Isosorbide Mononitrate | Isosorbide mononitrate is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure. |
| M5649 | Flubendazole | Flubendazole is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection. |
| M5380 | Aceglutamide | Aceglutamide is a precursor compound to glutamine that improves nerve cell metabolism. |
| M5196 | Spautin-1 | Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM. |
| M4844 | Isobavachalcone | Isobavachalcone (Corylifolinin) is a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma. |
| M4760 | Pterostilbene | Pterostilbene is an antioxidant that primarily exists in blueberries, grapevines and heartwood of red sandalwood. |
| M4745 | Lycopene | Lycopene, a carotenoid naturally occurring in tomatoes, other red fruits and vegetables, promotes autophagy by activating the PI3K-Akt signaling pathway, thereby slowing down AAI-induced renal fibrosis. It also possesses antioxidant, anti-inflammatory, antimicrobial and anti-aging activities. |
| M4733 | Phellodendrine-chloride | Phellodendrine chloride is an alkaloid in Phellodendron amurense. Phellodendrine chloride inhibited the proliferation of KRAS mutant pancreatic cancer cells by inhibiting the absorption of macropinocytosis. |
| M4704 | Diosgenin-glucoside | Diosgenin-glucoside is a saponin compound extracted from Tritulus terrestris L., protects against spinal cord injury by regulating autophagy and alleviating apoptosis. |
| M4702 | Corosolic acid | Corosolic acid is a pentacyclic triterpene acid found in Lagerstroemia speciosa, has antidiabetic, anti-inflammatory, antiproliferative, and protein kinase C inhibition activity. |
| M4592 | Xylitol | Xylitol can be classified as polyols and sugar alcohols. |
| M4585 | Taxifolin (TFN) | Taxifolin (TFN) is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM. |
| M4579 | Syringin | Syringin is one of the main bioactive phenolic glycosides in Acanthopanax senticosus and has anti-osteoporosis effect. Syringin prevents cardiac hypertrophy caused by pressure overload by inhibiting autophagy. |
| M4552 | Nobiletin | Nobiletin is a citrus flavonoid with anti-inflammatory, anti-cancer, cholesterol lowering, memory protection activities. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes. |
| M4548 | Vitexin | Vitexin is a C-glycosylated flavonoid found in a variety of medicinal plants such as Ficus deltoid and Spirulina (Spirodela polyrhiza). Vitexin has a wide range of pharmacological effects, including antioxidant, anticancer, anti-inflammatory, anti-hyperalgesia and neuroprotective effects. |
| M4544 | Typhaneoside | Typhaneoside, extracted from Typha Angustifolia L., inhibits autophagy in hypoxia/reoxygenation cells and increases the phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including lowering lipid levels, promoting anti-atherosclerotic activity, and improving immune and clotting function. |
| M4534 | Daurisoline | Daurisoline is an hERG inhibitor and also an autophagy inhibitor. |
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