Lycopene, a carotenoid naturally occurring in tomatoes, other red fruits and vegetables, promotes autophagy by activating the PI3K-Akt signaling pathway, thereby slowing down AAI-induced renal fibrosis. It also possesses antioxidant, anti-inflammatory, antimicrobial and anti-aging activities that
| Molecular Weight | 536.87 |
| Formula | C40H56 |
| CAS Number | 502-65-8 |
| Form | Solid |
| Storage | -80°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Ni Li, et al. Tomato and lycopene and multiple health outcomes: Umbrella review
[2] Mahdi Mirahmadi, et al. Potential inhibitory effect of lycopene on prostate cancer
[3] Ruyuan Zhu, et al. Lycopene in protection against obesity and diabetes: A mechanistic review
[4] Kristi M Crowe-White, et al. Lycopene and cognitive function
[5] Małgorzata Grabowska, et al. Let food be your medicine: nutraceutical properties of lycopene
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