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Aceglutamide

Cat. No. M5380
Aceglutamide Structure
Synonym:

α-N-Acetyl-L-glutamine, N2-Acetylglutamine

Size Price Availability Quantity
500mg USD 45  USD45 In stock
1g USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

Aceglutamide is a precursor compound to glutamine that improves nerve cell metabolism.

Chemical Information
Molecular Weight 188.18
Formula C7H12N2O4
CAS Number 2490-97-3
Form Solid
Solubility (25°C) 37 mg/mL warmed in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhang R, et al. Restor Neurol Neurosci. Neuroprotective effects of Aceglutamide on motor function in a rat model of cerebral ischemia and reperfusion.

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Keywords: Aceglutamide, α-N-Acetyl-L-glutamine, N2-Acetylglutamine supplier, Autophagy, inhibitors, activators


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