Inhibitor of Epstein-Barr virus early antigen (EBV-EA) induction. Isobavachalcone exhibits potent inhibitory effect on skin tumor promotion. Potent inhibitor of MMP-2. Displays DNA strand-scission (cleaving) activity. Isobavachalcone hows antifungal activity.
Cell Experiment | |
---|---|
Cell lines | E. aerogenes EA298 |
Preparation method | The lowest MIC values for diospyrone (4 μg/ml) and isobavachalcone (8 μg/ml) were recorded for E. coli AG100A and E. aerogenes EA298, respectively. |
Concentrations | 8 μg/ml |
Incubation time | 24 h |
Animal Experiment | |
---|---|
Animal models | male C57BL/6 mice |
Formulation | LPS |
Dosages | 50 and 10 mg/kg/day |
Administration | gavage |
Molecular Weight | 324.37 |
Formula | C20H20O4 |
CAS Number | 20784-50-3 |
Solubility (25°C) | 11 mg/mL in DMSO |
Storage | 2-8°C, protect from light |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Related Autophagy Products |
---|
P62-mediated mitophagy inducer
P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. |
FDW028
FDW028 is a potent and highly selective FUT8 inhibitor. FDW028 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the CMA pathway. |
Calmodulin-Dependent Protein Kinase II (290-309)
Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II. |
Microcolin H
Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. |
Forigerimod
Forigerimod (IPP-201101) is a CD4 T-cell modulator. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.