Free shipping on all orders over $ 500

Isobavachalcone

Cat. No. M4844
Isobavachalcone Structure
Synonym:

Corylifolinin; Isobacachalcone

Size Price Availability Quantity
5mg USD 77  USD77 In stock
10mg USD 130  USD130 In stock
25mg USD 260  USD260 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Inhibitor of Epstein-Barr virus early antigen (EBV-EA) induction. Isobavachalcone exhibits potent inhibitory effect on skin tumor promotion. Potent inhibitor of MMP-2. Displays DNA strand-scission (cleaving) activity. Isobavachalcone hows antifungal activity.

Protocol (for reference only)
Cell Experiment
Cell lines E. aerogenes EA298
Preparation method The lowest MIC values for diospyrone (4 μg/ml) and isobavachalcone (8 μg/ml) were recorded for E. coli AG100A and E. aerogenes EA298, respectively.
Concentrations 8 μg/ml
Incubation time 24 h
Animal Experiment
Animal models male C57BL/6 mice
Formulation LPS
Dosages 50 and 10 mg/kg/day
Administration gavage
Chemical Information
Molecular Weight 324.37
Formula C20H20O4
CAS Number 20784-50-3
Solubility (25°C) 11 mg/mL in DMSO
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jing H, et al. PLoS One. Isobavachalcone Attenuates MPTP-Induced Parkinson's Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway.

[2] Ohno O, et al. Biosci Biotechnol Biochem. Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from Piper longum on melanin production in B16 mouse melanoma cells.

[3] Kuete V, et al. Antimicrob Agents Chemother. Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.

Related Autophagy Products
P62-mediated mitophagy inducer

P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway.

FDW028

FDW028 is a potent and highly selective FUT8 inhibitor. FDW028 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the CMA pathway.

Calmodulin-Dependent Protein Kinase II (290-309)

Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.

Microcolin H

Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β.

Forigerimod

Forigerimod (IPP-201101) is a CD4 T-cell modulator.

  Catalog
Abmole Inhibitor Catalog




Keywords: Isobavachalcone, Corylifolinin; Isobacachalcone supplier, Autophagy, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.