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SMER 28

Cat. No. M7546
SMER 28 Structure
Size Price Availability Quantity
10mg USD 85  USD85 In stock
50mg USD 330  USD330 In stock
100mg USD 620  USD620 In stock
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Quality Control & Documentation
Biological Activity

SMER28 is an autophagy activator acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.

Protocol (for reference only)
Cell Experiment
Cell lines Mouse embryonic fibroblast (MEF) cells
Preparation method Cell lysates were analyzed by SDS-PAGE and Western blotting using anti-βCTF (6E10) and anti-tubulin antibodies. B, C) N2a-APP cells were treated with increasing concentrations of SMER28 for 16 h (B) or with a fixed concentration of SMER28 (50 μM) for various periods of time
Concentrations 50 μM
Incubation time 16 h
Animal Experiment
Animal models
Formulation
Dosages
Administration
Chemical Information
Molecular Weight 264.12
Formula C11H10BrN3
CAS Number 307538-42-7
Solubility (25°C) 32 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tian Y, et al. FASEB J. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway.

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Keywords: SMER 28 supplier, Autophagy, inhibitors, activators


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