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SMER28 is an autophagy activator acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide.
| Cell Experiment | |
|---|---|
| Cell lines | Mouse embryonic fibroblast (MEF) cells |
| Preparation method | Cell lysates were analyzed by SDS-PAGE and Western blotting using anti-βCTF (6E10) and anti-tubulin antibodies. B, C) N2a-APP cells were treated with increasing concentrations of SMER28 for 16 h (B) or with a fixed concentration of SMER28 (50 μM) for various periods of time |
| Concentrations | 50 μM |
| Incubation time | 16 h |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 264.12 |
| Formula | C11H10BrN3 |
| CAS Number | 307538-42-7 |
| Solubility (25°C) | 32 mg/mL in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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