Chloroquine

Biological Activity

Chloroquine is an inhibitor of autophagy and Toll-like receptors (TLRs). Chloroquine can effectively inhibit SARS-COV-2 infection (EC50=1.13 μM). Chloroquine is an anti-inflammatory widely used in malaria and rheumatoid arthritis.

Product Citations

• 

  Ecotoxicol Environ Saf. 2022 Jun 1;237:113564.

  Environmental BPDE induced human trophoblast cell apoptosis by up-regulating lnc-HZ01/p53 positive feedback loop
  Chloroquine purchased from AbMole

• 

  Adv Sci. 2021 Feb.

  Inhibition Lysosomal Degradation of Clusterin by Protein Kinase D3 Promotes Triple‐Negative Breast Cancer Tumor Growth
  Chloroquine purchased from AbMole

• 

  Life Sci. 2020 Nov 15;261:118484.

  Chloride channel 7 protects from redox status impairment-induced renal tubular epithelial cell apoptosis by activating autophagy
  Chloroquine purchased from AbMole

• 

  Anat Rec (Hoboken). 2020 Jan 21.

  Resibufogenin inhibited colorectal cancer cell growth and tumorigenesis through triggering ferroptosis and ROS production mediated by GPX4 inactivation
  Chloroquine purchased from AbMole

• 

  Int J Neurosci. 2020 Mar 11;1-15.

  Autophagy-deficiency in Bone Marrow Mononuclear Cells From Patients With Myasthenia Gravis: A Possible Mechanism of Pathogenesis.
  Chloroquine purchased from AbMole

Chemical Information

Molecular Weight	319.87
Formula	C18H26ClN3
CAS Number	54-05-7
Solubility (25°C)	DMSO ≥ 50 mg/mL
Storage	4°C, dry, protect from light, sealed

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Paulo Michel Pinheiro Ferreira, et al. Chloroquine and hydroxychloroquine in antitumor therapies based on autophagy-related mechanisms

[2] Winnie Fong, et al. Repurposing Chloroquine Analogs as an Adjuvant Cancer Therapy

[3] Gricelis P Martinez, et al. The Role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases

[4] Bruno Mgarbane. Chloroquine and hydroxychloroquine to treat COVID-19: between hope and caution

[5] Franck Touret, et al. Of chloroquine and COVID-19