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Chloroquine

Cat. No. M9559
Chloroquine Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 40  USD40 In stock
50mg USD 45  USD45 In stock
100mg USD 58  USD58 In stock
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Quality Control & Documentation
Biological Activity

Chloroquine is an inhibitor of autophagy and Toll-like receptors (TLRs). Chloroquine can effectively inhibit SARS-COV-2 infection (EC50=1.13 μM). Chloroquine is an anti-inflammatory widely used in malaria and rheumatoid arthritis.

Product Citations
Chemical Information
Molecular Weight 319.87
Formula C18H26ClN3
CAS Number 54-05-7
Solubility (25°C) DMSO ≥ 50 mg/mL
Storage 4°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Paulo Michel Pinheiro Ferreira, et al. Chloroquine and hydroxychloroquine in antitumor therapies based on autophagy-related mechanisms

[2] Winnie Fong, et al. Repurposing Chloroquine Analogs as an Adjuvant Cancer Therapy

[3] Gricelis P Martinez, et al. The Role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases

[4] Bruno Mgarbane. Chloroquine and hydroxychloroquine to treat COVID-19: between hope and caution

[5] Franck Touret, et al. Of chloroquine and COVID-19

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Keywords: Chloroquine supplier, Autophagy, inhibitors, activators

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