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Chloroquine

Cat. No. M9559
Chloroquine Structure
Size Price Availability Quantity
10mM*1mL USD 56.25  USD62.5 In stock
50mg USD 45  USD50 In stock
100mg USD 56.25  USD62.5 In stock
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Quality Control
Biological Activity

Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis, it is also a autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine (CHQ, 20 μM) inhibits IL-12p70 release and reduces Th1-priming capacity of activated human monocyte-derived Langerhans-like cells (MoLC). Chloroquine (20 μM) enhances IL-1–induced IL-23 secretion in MoLC and subsequently increases IL-17A release by primed CD4+ T cells. Chloroquine (25 μM) suppresses MMP-9 mRNA expression in normoxia and hypoxia in parental MDA-MB-231 cells. In vivo, Chloroquine (80 mg/kg, i.p.) does not prevent the growth of the triple-negative MDA-MB-231 cells with high or low TLR9 expression levels in the orthotopic mouse model.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 319.87
Formula C18H26ClN3
CAS Number 54-05-7
Purity >99%
Solubility DMSO ≥ 50 mg/mL
Storage 4°C, dry, protect from light, sealed
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Chloroquine supplier, Autophagy, inhibitors

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