Chloroquine is an inhibitor of autophagy and Toll-like receptors (TLRs). Chloroquine can effectively inhibit SARS-COV-2 infection (EC50=1.13 μM). Chloroquine is an anti-inflammatory widely used in malaria and rheumatoid arthritis.
Ecotoxicol Environ Saf. 2022 Jun 1;237:113564.
Environmental BPDE induced human trophoblast cell apoptosis by up-regulating lnc-HZ01/p53 positive feedback loop
Chloroquine purchased from AbMole
Adv Sci. 2021 Feb.
Inhibition Lysosomal Degradation of Clusterin by Protein Kinase D3 Promotes Triple‐Negative Breast Cancer Tumor Growth
Chloroquine purchased from AbMole
Life Sci. 2020 Nov 15;261:118484.
Chloride channel 7 protects from redox status impairment-induced renal tubular epithelial cell apoptosis by activating autophagy
Chloroquine purchased from AbMole
Anat Rec (Hoboken). 2020 Jan 21.
Resibufogenin inhibited colorectal cancer cell growth and tumorigenesis through triggering ferroptosis and ROS production mediated by GPX4 inactivation
Chloroquine purchased from AbMole
Int J Neurosci. 2020 Mar 11;1-15.
Autophagy-deficiency in Bone Marrow Mononuclear Cells From Patients With Myasthenia Gravis: A Possible Mechanism of Pathogenesis.
Chloroquine purchased from AbMole
Molecular Weight | 319.87 |
Formula | C18H26ClN3 |
CAS Number | 54-05-7 |
Solubility (25°C) | DMSO ≥ 50 mg/mL |
Storage | 4°C, dry, protect from light, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Winnie Fong, et al. Repurposing Chloroquine Analogs as an Adjuvant Cancer Therapy
[4] Bruno Mgarbane. Chloroquine and hydroxychloroquine to treat COVID-19: between hope and caution
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