| Cat.No. | Name | Information |
|---|---|---|
| M1934 | Tacrolimus (FK506) | Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. *The compound is unstable in solutions, freshly prepared is recommended |
| M3380 | Pitavastatin Calcium | Pitavastatin Calcium is a new type of statin. |
| M3497 | Simvastatin (MK 733) | Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. Simvastatin inhibits exosome release. Prior to use in cell assays, Simvastatin needs to be activated by NaOH in EtOH treatment. |
| M2510 | Chloroquine diphosphate | Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent. |
| M9559 | Chloroquine | Chloroquine is an inhibitor of autophagy and Toll-like receptors (TLRs). Chloroquine can effectively inhibit SARS-COV-2 infection (EC50=1.13 μM). Chloroquine is an anti-inflammatory widely used in malaria and rheumatoid arthritis. |
| M9765 | Dimethyl itaconate | Dimethyl itaconate may be used in functionalization of isotactic poly(propylene). |
| M9059 | TBHQ | TBHQ is an aromatic organic compound, as a selective inducer of Nrf2 in a preclinical model of ICH. TBHQ (tert-Butylhydroquinone) is also an ERK activator. |
| M2049 | Metformin hydrochloride | Metformin HCl is a biguanide inhibitor that reduces blood glucose mainly by inhibiting hepatic glycogen production (hepatic gluconeogenesis), while Metformin is a CD47 inhibitor in vitro. |
| M9069 | AS1842856 | AS1842856 is a cell-permeable Foxo1 inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. |
| M5961 | Silibinin | Silibinin, the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury. |
| M4522 | Ursolic acid | Ursolic acid (Prunol) is a natural triterpenoid carboxylic acid compound with preventive and anticancer activities. Ursolic acid also has proteasome agonist activity, EC50=14 μmol/L. |
| M4498 | Hydroxysafflor-yellow-A | Hydroxysafflor-yellow-A (HSYA) is a water-soluble component of safflower, which has various pharmacological activities such as inhibiting platelet aggregation, anti-oxidation, and anti-inflammatory. Hydroxysafflor yellow A can inhibit cell proliferation and promote apoptosis through the autophagy pathway. |
| M4430 | Ligustilide | Ligustilide is a bioactive phthalate derivative isolated from Angelica sinensis and Ligusticum chuanxiong. Ligustilide has neuroprotective, anticancer, anti-inflammatory and vasodilatation effects. *The compound is unstable in solutions, freshly prepared is recommended |
| M4394 | Wogonoside | Wogonoside is a flavonoid glycoside isolated from Scutellaria baicalensis and has anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating the MAPK-MTOR pathway. |
| M4264 | Peiminine | Peiminine is a natural compound with anti-inflammatory activity. |
| M4246 | Schisandrin | Schisandrin (Schizandrin) isa biphenyl cycloctene lignan isolated from the fruit of Schisandra chinensis. Schisandrin has antioxidant, hepatoprotective, anticancer and anti-inflammatory activities. Schisandrin also reversed memory problems in rats. |
| M4245 | Schizandrin-B | Schisandrin B (γ-Schisandrin) isa diphenyl cycloctadiene derivative isolated from schisandra chinensis and has been shown to have antioxidant effects on the liver and heart of rodents. |
| M4227 | Liensinine | Liensinine is an autophagy/mitophagy inhibitor. |
| M4190 | Onjisaponin-B | Onjisaponin B isa natural product extracted from Polygonum. In PC-12 cells, Onjisaponin B can promote autophagy and accelerate the degradation of mutant α -synuclein and Huntington protein, which can be used to study Parkinson's disease and Huntington's disease. |
| M4140 | Salvianolic-acid-B | Salvianolic acid B is a cell protective antioxidant and free radical scavenger being investigated for a variety of conditions from ischemic heart disorders to Alzheimer′s disease. *The compound is unstable in solutions, freshly prepared is recommended. |
| M4105 | Alisol-A | Alisol A is A natural product. |
| M4012 | Licochalcone-A | Licochalcone A is an estrogenic flavonoid derived from licorice that induces Nrf2-mediated defense mechanisms and ameliorates acetaminophen and endotoxin-induced liver injury. In addition, Licochalcone A has antimalarial, anticancer, antibacterial and antiviral activities. |
| M3921 | Dioscin | Dioscin (CCRIS 4123, Collettiside III) is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines. |
| M3913 | Sophocarpine | Sophocarpine is a HERG K+ channel blocker with IC50 of 100-300 μM and Na+ channel inward current inhibitor. |
| M3499 | Ezetimibe | Ezetimibe (Zetia) is a beta-lactam analog that targets NPC1L1, thereby lowering blood cholesterol levels. In addition, Ezetimibe can prevent spinal cord injury by inhibiting apoptosis through activation of autophagy and modulation of the PI3K/AKT/mTOR signaling pathway, which can be used in studies related to spinal cord injury. |
| M3327 | Genipin | Genipin is an active aglycone derived from an iridoid glycoside called geniposide, which is found in the fruit of Gardenia jasminoides Ellis. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. |
| M3055 | Tempol | TEMPOL is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. |
| M2659 | E-64 | E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain. |
| M2450 | Bergapten | Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication. |
| M2256 | Ivermectin (MK-933) | Ivermectin (MK-933) is a positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Importin α5 inhibitor ivermectin effectively abrogates STAT1-importin α5 interactions. |
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