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Autophagy Autophagy

Cat.No.  Name Information
M1934 Tacrolimus (FK506) Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. *The compound is unstable in solutions, freshly prepared is recommended
M3380 Pitavastatin Calcium Pitavastatin Calcium is a new type of statin.
M3497 Simvastatin (MK 733) Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. Simvastatin inhibits exosome release. Prior to use in cell assays, Simvastatin needs to be activated by NaOH in EtOH treatment.
M2510 Chloroquine diphosphate Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent.
M9559 Chloroquine Chloroquine is an inhibitor of autophagy and Toll-like receptors (TLRs). Chloroquine can effectively inhibit SARS-COV-2 infection (EC50=1.13 μM). Chloroquine is an anti-inflammatory widely used in malaria and rheumatoid arthritis.
M9765 Dimethyl itaconate Dimethyl itaconate may be used in functionalization of isotactic poly(propylene).
M9059 TBHQ TBHQ is an aromatic organic compound, as a selective inducer of Nrf2 in a preclinical model of ICH. TBHQ (tert-Butylhydroquinone) is also an ERK activator.
M2049 Metformin hydrochloride Metformin HCl is a biguanide inhibitor that reduces blood glucose mainly by inhibiting hepatic glycogen production (hepatic gluconeogenesis), while Metformin is a CD47 inhibitor in vitro.
M9069 AS1842856 AS1842856 is a cell-permeable Foxo1 inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM.
M5961 Silibinin Silibinin, the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury.
M4012 Licochalcone-A Licochalcone A is an estrogenic flavonoid derived from licorice that induces Nrf2-mediated defense mechanisms and ameliorates acetaminophen and endotoxin-induced liver injury. In addition, Licochalcone A has antimalarial, anticancer, antibacterial and antiviral activities.
M3921 Dioscin Dioscin (CCRIS 4123, Collettiside III) is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines.
M3913 Sophocarpine Sophocarpine is a HERG K+ channel blocker with IC50 of 100-300 μM and Na+ channel inward current inhibitor.
M3539 Verteporfin (CL 318952) Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin (CL 318952) is a YAP inhibitor that disrupts YAP-TEAD interactions, and it is also an inhibitor of autophagy.
M3499 Ezetimibe Ezetimibe (Zetia) is a beta-lactam analog that targets NPC1L1, thereby lowering blood cholesterol levels. In addition, Ezetimibe can prevent spinal cord injury by inhibiting apoptosis through activation of autophagy and modulation of the PI3K/AKT/mTOR signaling pathway, which can be used in studies related to spinal cord injury.
M3327 Genipin Genipin is an active aglycone derived from an iridoid glycoside called geniposide, which is found in the fruit of Gardenia jasminoides Ellis.
M3055 Tempol TEMPOL is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects.
M2659 E-64 E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain.
M2450 Bergapten Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication.
M2256 Ivermectin (MK-933) Ivermectin (MK-933) is a positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Importin α5 inhibitor ivermectin effectively abrogates STAT1-importin α5 interactions.
M54772 P62-mediated mitophagy inducer P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway.
M54633 FDW028 FDW028 is a potent and highly selective FUT8 inhibitor. FDW028 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the CMA pathway.
M53364 Calmodulin-Dependent Protein Kinase II (290-309) Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.
M53363 Microcolin H Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β.
M53362 Forigerimod Forigerimod (IPP-201101) is a CD4 T-cell modulator.
M45399 CUR5g CUR5g is a potent autophagy inhibitor that selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion. CUR5g also prevents STX17 from being recruited to autophagosomes through a UVRAG-dependent mechanism, resulting in the inability of autophagosomes to fuse with lysosomes. In addition, CUR5g enhances the in vitro and in vivo anticancer effects of cisplatin in A549 cells.
M45008 Sotetsuflavone Sotetsuflavone is a flavonoid that can be isolated from Cycas revolute.
M44869 Guaiol Guaiol is a sesquiterpene alcohol that has been found in several traditional Chinese medicinal plants and has antiproliferative, pro-autophagic, insect repellent, and insecticidal biological activities.
M41414 HDAC-IN-62 HDAC-IN-62 a HDAC inhibitor, with IC50s of 0.78, 1.0, 1.2? μM for HDAC6/8/11 respectively.
M41413 HDAC10-IN-2 hydrochloride HDAC10-IN-2 hydrochloride is a potent and highly selective HDAC10 inhibitor, with an IC50 of 20 nM.




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