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Licochalcone-A

Cat. No. M4012
Licochalcone-A Structure
Synonym:

Licochalcone-A; Lico A

Size Price Availability Quantity
20mg USD 150  USD150 In stock
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Biological Activity

Licochalcone A is an estrogenic flavonoid derived from licorice that induces Nrf2-mediated defense mechanisms and ameliorates acetaminophen and endotoxin-induced liver injury. In addition, Licochalcone A has antimalarial, anticancer, antibacterial and antiviral activities.

Chemical Information
Molecular Weight 338.4
Formula C21H22O4
CAS Number 58749-22-7
Form Solid
Solubility (25°C) 67 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xueshuang Liu, et al. Licochalcone A inhibits proliferation and promotes apoptosis of colon cancer cell by targeting programmed cell death-ligand 1 via the NF-κB and Ras/Raf/MEK pathways

[2] Shuai Gong, et al. Licochalcone A is a Natural Selective Inhibitor of Arginine Methyltransferase 6

[3] Chian-Jiun Liou, et al. Protective Effects of Licochalcone A Ameliorates Obesity and Non-Alcoholic Fatty Liver Disease Via Promotion of the Sirt-1/AMPK Pathway in Mice Fed a High-Fat Diet

[4] Hongming Lv, et al. Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A

[5] Kornphaka Kantikosum, et al. The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study

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Keywords: Licochalcone-A, Licochalcone-A; Lico A supplier, Autophagy, inhibitors, activators

 
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