Silibinin, the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury. Silibinin is an effective SARS-CoV-2 main protease (Mpro) inhibitor. Silibinin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance.
J Adv Res. 2022 May 13;S2090-1232(22)00117-5.
Combination of natural polyphenols with a precursor of NAD+ and a TLR2/6 ligand lipopeptide protects mice against lethal γ radiation
Silibinin purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Athymic (nu/nu) male nude mice s.c. injected with 6 × 106 DU145 cells |
| Formulation | 0.5% CMC (w/v) in saline |
| Dosages | 200 mg/kg |
| Administration | oral gavage just before the first dose of IR and continued for 5 days/week |
| Molecular Weight | 482.44 |
| Formula | C25H22O10 |
| CAS Number | 22888-70-6 |
| Solubility (25°C) | DMSO 96 mg/mL |
| Storage | Powder -20°C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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