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Silibinin

Cat. No. M5961

All AbMole products are for research use only, cannot be used for human consumption.

Silibinin Structure
Synonym:

Silymarin; Silybin; Silybin A

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 40  USD40 In stock
500mg USD 70  USD70 In stock
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Quality Control & Documentation
Biological Activity

Silibinin, the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury. Silibinin is an effective SARS-CoV-2 main protease (Mpro) inhibitor. Silibinin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance.

Product Citations
Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Athymic (nu/nu) male nude mice s.c. injected with 6 × 106 DU145 cells
Formulation 0.5% CMC (w/v) in saline
Dosages 200 mg/kg
Administration oral gavage just before the first dose of IR and continued for 5 days/week
Chemical Information
Molecular Weight 482.44
Formula C25H22O10
CAS Number 22888-70-6
Solubility (25°C) DMSO 96 mg/mL
Storage Powder -20°C
References

[1] Nambiar DK, et al. Mol Cancer Ther. Silibinin Preferentially Radiosensitizes Prostate Cancer by Inhibiting DNA Repair Signaling.

[2] Abdul Quaiyoom Khan, et al. Nutr Cancer. Silibinin inhibits tumor promotional triggers and tumorigenesis against chemically induced two-stage skin carcinogenesis in Swiss albino mice: possible role of oxidative stress and inflammation

[3] Khaled Khazim, et al. Am J Physiol Renal Physiol. The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo

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Keywords: Silibinin, Silymarin; Silybin; Silybin A supplier, Autophagy, inhibitors, activators

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