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Dioscin

Cat. No. M3921
Dioscin Structure
Synonym:

CCRIS 4123, Collettiside III

Size Price Availability Quantity
5mg USD 48  USD48 In stock
10mg USD 75  USD75 In stock
50mg USD 250  USD250 In stock
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Quality Control & Documentation
Biological Activity

Dioscin suppressed HL-60 cell growth in a dose-dependent manner. Dioscin induces apoptosis by activation of p38 MAPK and JNK through the caspase-dependent mitochondrial death pathway. Dioscin may be used as a compound lead for the treatment of myeloblast leukemia. Dioscin may be a potential anticancer drug, which efficiently inhibits angiogenesis induced by VEGFR2 signaling pathway as well as AKT/MAPK pathways. Dioscin alleviated body weight and liver lipid accumulation symptoms, increased oxygen consumption and energy expenditure, and improved the levels of serum and hepatic biochemical parameters. Dioscin significantly attenuated oxidative damage, suppressed inflammation, inhibited triglyceride and cholesterol synthesis, promoted fatty acid β-oxidation, down-regulated MAPK phosphorylation levels, and induced autophagy to alleviate fatty liver conditions. Dioscin prevents diet induced obesity and NAFLD by increasing energy expenditure.

Chemical Information
Molecular Weight 869.04
Formula C45H72O16
CAS Number 19057-60-4
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Liu M, et al. Sci Rep. Potent effects of dioscin against obesity in mice.

[2] Poudel B, et al. Int J Mol Med. Dioscin inhibits adipogenesis through the AMPK/MAPK pathway in 3T3-L1 cells and modulates fat accumulation in obese mice.

[3] Tong Q, et al. Toxicol Appl Pharmacol. Dioscin inhibits colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways.

[4] Tao X, et al. Transplantation. Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.

[5] Kim EA, et al. Apoptosis. Dioscin induces caspase-independent apoptosis through activation of apoptosis-inducing factor in breast cancer cells.

[6] Wang Y, et al. Eur J Pharmacol. Dioscin induced activation of p38 MAPK and JNK via mitochondrial pathway in HL-60 cell line.

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Keywords: Dioscin, CCRIS 4123, Collettiside III supplier, Autophagy, inhibitors, activators


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