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GW406108X is a potent autophagy inhibitor, with a pIC50 6.37 (427 nM) against ULK1. GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signalling kinases mTORC1 and AMPK. GW406108X inhibits VPS34 and AMPK with pIC50 of 6.34 (457 nM) and 6.38 (417 nM), respectively.
| Molecular Weight | 400.21 |
| Formula | C20H11Cl2NO4 |
| CAS Number | 1644443-92-4 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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