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Corynoxine B

Cat. No. M11124
Corynoxine B Structure
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10mg USD 275  USD275 In stock
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Biological Activity

Corynoxine B is a natural compound of indole alkaloid, a beclin-1-dependent autophagy inducer.

Chemical Information
Molecular Weight 384.48
Formula C22H28N2O4
CAS Number 17391-18-3
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhou Zhu, et al. Acta Pharmacol Sin. Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy

[2] Soumen Chakraborty, et al. ACS Chem Neurosci. Kratom Alkaloids as Probes for Opioid Receptor Function: Pharmacological Characterization of Minor Indole and Oxindole Alkaloids from Kratom

[3] Dongying Yan, et al. Food Chem Toxicol. Corynoxine B ameliorates HMGB1-dependent autophagy dysfunction during manganese exposure in SH-SY5Y human neuroblastoma cells

[4] Zhiying Wang, et al. Electrophoresis. Separation and determination of corynoxine and corynoxine B using chiral ionic liquid and hydroxypropyl-β-cyclodextrin as additives by field-amplified sample stacking in capillary electrophoresis

[5] Jun Xu, et al. J Am Chem Soc. Construction of tetracyclic 3-spirooxindole through cross-dehydrogenation of pyridinium: applications in facile synthesis of (±)-corynoxine and (±)-corynoxine B

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Keywords: Corynoxine B supplier, Autophagy, inhibitors, activators

 
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