Free shipping on all orders over $ 500

EN6

Cat. No. M10277

All AbMole products are for research use only, cannot be used for human consumption.

EN6 Structure
Synonym:

ABM-4739

Size Price Availability Quantity
1mg USD 50  USD50 In stock
5mg USD 105  USD105 In stock
10mg USD 165  USD165 In stock
50mg USD 330  USD330 In stock
100mg USD 480  USD480 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy.

Chemical Information
Molecular Weight 368.34
Formula C19H14F2N4O2
CAS Number 1808714-73-9
Form Solid
Solubility (25°C) DMSO 4 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Clive Yik-Sham Chung, et al. Nat Chem Biol. Covalent targeting of the vacuolar H +-ATPase activates autophagy via mTORC1 inhibition

Related Autophagy Products
Vacuolin-1

Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. Vacuolin-1 blocks the Ca2+-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. vacuolin‐1 is a potent and selective PIKfyve inhibitor and inhibits late‐stage autophagy by impairing lysosomal maturation.

CA77.1 

CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics.

KAN0438757 

KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.

Metofenazate

Metofenazate is a selective calmodulin inhibitor.

Patulin

Patulin (Terinin) is a mycotoxin produced by a variety of fungi, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage.

  Catalog
Abmole Inhibitor Catalog




Keywords: EN6, ABM-4739 supplier, Autophagy, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.