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EN6

Cat. No. M10277
EN6 Structure
Synonym:

ABM-4739

Size Price Availability Quantity
5mg USD 97  USD97 In stock
10mg USD 165  USD165 In stock
50mg USD 330  USD330 In stock
100mg USD 495  USD495 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 368.34
Formula C19H14F2N4O2
CAS Number 1808714-73-9
Purity >99%
Solubility DMSO 4 mg/mL
Storage at -20°C
References

[1] Clive Yik-Sham Chung, et al. Nat Chem Biol. Covalent targeting of the vacuolar H +-ATPase activates autophagy via mTORC1 inhibition

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: EN6, ABM-4739 supplier, Autophagy, inhibitors

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