About 30 results found for searched term "EN6" (0.008 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1706 | ENMD-2076 | Aurora Kinase |
| ENMD-2076 is an orally-active, Aurora A/angiogenic kinase inhibitor. | ||
| M1708 | Selisistat | Sirtuin |
| EX 527; SEN0014196 | ||
| Selisistat (EX 527) is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 98 nM. | ||
| M2100 | Bleomycin sulfate | Animal Modeling |
| Blenoxane; NSC125066; BLEO | ||
| Bleomycin sulfate (Blenoxane) is a glycopeptide antitumor antibiotic isolated from Streptomyces verticillus. | ||
| M2280 | Tamoxifen Citrate (ICI 46474) | Estrogen Receptor |
| ICI 46474; Istubal; Nolvadex | ||
| Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding. | ||
| M2377 | Altrenogest | Progesterone Receptor |
| A35957; Allyltrenbolone; R2267; RU2267 | ||
| Altrenogest is a progestogen structurally related to veterinary steroid trenbolone. | ||
| M2381 | AMD3465 hexahydrobromide (AMD3465 ) | CXCR |
| GENZ-644494 hexahydrobromide | ||
| AMD3465 hexahydrobromide（AMD3465 ) is an effective CXCR4 antagonist that inhibits 12G5 mAb in SupT1 cells. The IC50 values of CXCL12AF647 and CXCR4 were 0.75 nM and 18 nM, respectively. AMD 3465 also effectively inhibited X4 HIV replication (IC50, 1-10 nM), but not R5 HIV replication. | ||
| M2570 | Tenovin-6 | p53 |
| Tenovin-6 is a small molecule activator of p53 transcriptional activity. | ||
| M3026 | Sorafenib (BAY 43-9006) | Raf |
| BAY 43-9006 | ||
| Sorafenib (BAY 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. Sorafenib is a multikinase inhibitor with IC50 values of 15 nM, 20 nM, 57 nM and 58 nM for VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib is a ferroptosis activator. | ||
| M3173 | Potassium canrenoate | Mineralocorticoid Receptor |
| Aldadiene potassium, SC-14266 | ||
| Canrenoate potassium is a predrug for the release of Canrenone and an effective antagonist of competitive salt ocorticoid receptor. As a diuretic, Canrenoate potassium is used in the study of hypertension. | ||
| M3265 | Olmesartan | Angiotensin Receptor |
| Benicar; Olmetec; RNH-6270 | ||
| Olmesartan is an angiotensin II receptor antagonist with an IC50 of 7.7 nM. | ||
| M3272 | Alendronate sodium hydrate | Others |
| Alendronate; MK 217; G-704650 Adronat | ||
| Alendronate is a farnesyl diphosphate synthase inhibitor with IC50 of 460 nM. | ||
| M3416 | Mycophenolic acid | Immunology/Inflammation |
| Mycophenolate, RS-61443; MPA | ||
| Mycophenolic acid is an immunosuppressant agent used to prevent rejection in organ transplantation. | ||
| M3784 | Genz-644282 | Topoisomerase |
| Genz 644282 is a novel non-camptothecin topoisomerase I inhibitor with an IC50 value of 0.4 nM in human bone marrow CFU-GM assay. | ||
| M4091 | Ginsenoside-Rg6 | NF-κB |
| Ginsenoside Rg6 inhibited NF-κB transcriptional activity induced by TNF-α in HepG2 cells with IC50 of 29.34 μM. Ginsenoside Rg6 also induced apoptosis. | ||
| M4540 | Scutellarein | Src-bcr-Abl |
| 6-Hydroxyapigenin; 4',5,6,7-Tetrahydroxyflavone | ||
| Scutellarein is a natural flavonoid with anti-inflammatory effects. | ||
| M4626 | Prosapogenin-CP6 | Others |
| Prosapogenin CP6 is a natural product. | ||
| M4812 | Genz-123346 | Others |
| Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1. | ||
| M4925 | Enoxacin hydrate | Antibiotic |
| Enoxacin sesquihydrate; AT-2266 hydrate; CI-919 hydrate | ||
| Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent. | ||
| M4991 | Dihydroartemisinin | Parasite |
| β-Dihydroartemisinin; DHA; Artenimol; CAS# 81496-82-4 | ||
| Dihydroartemisinin is a potent anti-malaria agent. Dihydroartemisinin, a derivative of artemisinin in which the C-10 lactone group is replaced by hemiacetals and active metabolites of all artemisinin compounds, is a widely used antimalarial compound that effectively induces iron death in acute myeloid leukemia cells (HL60, KG1, and THP-1) by regulating iron metabolism. | ||
| M5267 | E7449 | PARP |
| Stenoparib; 2X-121; MGI25036 | ||
| E7449 is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 that also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively. | ||
| M5374 | 6-Benzylaminopurine | Plant growth regulators |
| 6-BAP; BA; N6-Benzyladenine; Benzyladenine; 6-BA | ||
| 6-Benzylaminopurine is a first-generation synthetic cytokinin which could regulate the activities of the antioxidant defense system of plants.Its treatment elicits plant growth and development. | ||
| M5490 | Cefmenoxime HCl | Antibiotic |
| Cefmenoxime hemihydrochloride, SCE-1365 hemihydrochloride | ||
| Cefmenoxime, a potent inhibitor of Enterobacteriaceae, is a cephalosporin antibiotic that is administered intravenously or intramuscularly. | ||
| M5510 | Chlorindione | Others |
| Chlophenadione; Indaliton; G-25766 | ||
| Chlophenadione is a potent anticoagulant compound. | ||
| M5564 | Desogestrel | Estrogen Receptor |
| Cerazette, Desogen, Desogestrelum, Org-2969 | ||
| Desogestrel is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents. | ||
| M5610 | Eliglustat | Glucosylceramide Synthase |
| GENZ-112638 | ||
| Eliglustat inhibits glucosylceramide synthase (GCS), thus reducing the load of glucosylceramide influx into the lysosome. | ||
| M6127 | TD-4208 | AChR/AChE |
| Revefenacin; GSK1160724 | ||
| Revefenacin (TD-4208; GSK1160724) is a novel and potent muscarinic receptor antagonist that has a high affinity and long residence time at the M3 receptor, and demonstrates in vitro kinetic selectivity for M3 over M2 muscarinic receptor subtype and no meaningful off-target activity. | ||
| M6184 | Dutetrabenazine | Others |
| Tetrabenazine D6; Ro 1-9569 D6 | ||
| Deutetrabenazine is the deuterium labeled Tetrabenazine, which is a VMAT-inhibitor used for the research of hyperkinetic movement disorder. | ||
| M6241 | Tenovin 6 Hydrochloride | Sirtuin |
| Tenovin-6 Hydrochloride is a water soluble inhibitor of SIRT1 and SIRT2, slightly inhibits HDAC8, and is also a potent activator of p53, with IC50s of 21 μM, 10 μM, 67 μM for SirT1, SirT2, and SirT3, respectively. | ||
| M6280 | Brequinar | DHODH |
| DUP785; Biphenquinate; BPQ；NSC 368390 | ||
| Brequinar is an effective Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 5.2 nM for human DHODH, and a broad-spectrum antiviral agent. | ||
| M6389 | 1-Aminobenzotriazole (ABT) | Cytochrome P450 (e.g. CYP17) |
| ABT; 3-Aminobenzotriazole; 1-Benzotriazolylamine; NSC 114498; NSC 656987 | ||
| 1-Aminobenzotriazole (ABT) is a cytochrome P450 inhibitor; inhibits 20-HETE synthesis. | ||
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