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QX77 is a novel chaperone-mediated autophagy (cma) activator. QX77 dysregulates the repressive function of retinoic acid receptor-alpha over the cma machinery, inducing the significant upregulation of megalin expression in cystinotic ptcs, rescuing the defective trafficking phenotype in ctns-ko ptcs. Treatment with CMA activator QX77 rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells. QX77 treatment also increases LAMP2A localization at the lysosomal membrane.
Cell Biochem Biophys. 2025 Feb 25; .
Chaperone-Mediated Autophagy Reactivation Protects Against Severe Acute Pancreatitis-Associated Liver Injury Through Upregulating Keap1/Nrf2 Signaling Pathway and Inhibiting NLRP3 Inflammasome Activation
QX77 purchased from AbMole
| Molecular Weight | 300.74 |
| Formula | C16H13ClN2O2 |
| CAS Number | 1798331-92-6 |
| Solubility (25°C) | DMSO ≥ 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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