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Remdesivir

Cat. No. M3864
Remdesivir Structure
Synonym:

GS-5734

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
1mg USD 40  USD50 In stock
5mg USD 72  USD90 In stock
10mg USD 104  USD130 In stock
50mg USD 288  USD360 In stock
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Biological Activity

Remdesivir, also known as GS-5734, is a nucleoside analogue with in vitro activity against multiple RNA viruses, including Ebola and CoV. Remdesivir inhibits murine hepatitis virus (MHV) with an EC50 of 30 nM, and blocks SARS-CoV and MERS-CoV in HAE cells with EC50s of both 74 nM in HAE cells after treatment for 24 h. GS-5734 inhibits both epidemic and zoonotic coronaviruses. Remdesivir may be highly effective in the control of 2019-nCoV (COVID-19) infection in vitro.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 602.58
Formula C27H35N6O8P
CAS Number 1809249-37-3
Purity 100.00%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] Wang M, et al. Cell Res. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.

[2] Agostini ML, et al. mBio. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.

[3] Warren TK, et al. Nature. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys.

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