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Remdesivir, also known as GS-5734, is a nucleoside analogue with in vitro activity against multiple RNA viruses, including Ebola and CoV. Remdesivir inhibits murine hepatitis virus (MHV) with an EC50 of 30 nM, and blocks SARS-CoV and MERS-CoV in HAE cells with EC50s of both 74 nM in HAE cells after treatment for 24 h. GS-5734 inhibits both epidemic and zoonotic coronaviruses. Remdesivir may be highly effective in the control of 2019-nCoV (COVID-19) infection in vitro.
| Molecular Weight | 602.58 |
| Formula | C27H35N6O8P |
| CAS Number | 1809249-37-3 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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