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Boceprevir

Cat. No. M3624
Boceprevir Structure
Synonym:

EBP-520, SCH503034

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 67.5  USD75 In stock
5mg USD 54  USD60 In stock
10mg USD 73.8  USD82 In stock
50mg USD 190.8  USD212 In stock
100mg USD 289.8  USD322 In stock
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Quality Control
Biological Activity

Boceprevir (EBP-520, SCH503034) is an HCV protease inhibitor (Ki=14 nM) for the treatment of hepatitis C virus infection. Boceprevir with pegylated interferon and ribavirin (PegIFN/RBV) enabled improvement in sustained virological response rates of patients with genotype 1 HCV. Boceprevir interacts with immunosuppressive therapy (IT) by inhibiting the cytochrome P450 3A enzyme.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 519.68
Formula C27H45N5O5
CAS Number 394730-60-0
Purity >99%
Solubility DMSO 15 mg/mL
Storage -20°C, protect from light, sealed
References

Practical management of boceprevir and immunosuppressive therapy in liver transplant recipients with hepatitis C virus recurrence.
Coilly A, et al. Antimicrob Agents Chemother. 2012 Nov;56(11):5728-34. PMID: 22908172.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Boceprevir, EBP-520, SCH503034 supplier, HCV Protease, inhibitors

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