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HCV Protease HCV Protease

Cat.No.  Name Information
M22452 2'-C-Methyladenosine 2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication, it inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC50 values of 0.3 μM and 1.9 μM, respectively.
M20732 Pibrentasvir (ABT-530) Pibrentasvir (ABT-530) is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with EC50 ranging from 1.4 pM to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6.
M20529 Glecaprevir Glecaprevir is a hepatitis C virus (HCV) nonstructural (NS) protein 3/4A protease inhibitor that targets the the viral RNA replication. It displays IC50 values ranging from 3.5 to 11.3 nM for clinical isolates of HCV genotypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, and 6a.
M9758 Merimepodib Merimepodib, also known as VX-497, is an orally bioavailable IMPDH inhibitor with broad spectrum antiviral activities.
M9530 Inarigivir soproxil Inarigivir soproxil, also known as SB 9200, is a novel agonist of innate immunity, which shows potent antiviral activity against resistant HCV variants.
M8881 Ombitasvir Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a.
M8880 Paritaprevir Paritaprevir (ABT-450) is a potent non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50 values of 1 and 0.21 nM for HCV 1a and 1b, respectively.
M6191 Velpatasvir Velpatasvir is a second-generation NS5A inhibitor that inhibits hepatitis C viral replication through acting on the crucial "membranous web" that facilitates RNA replication.
M4691 Lycorine hydrochloride Lycorine hydrochloride is a natural alkaloid extracted from Amaryllidaceae (Amaryllidaceae) plants. It is a strong HCV inhibitor and melanoma angiogenesis inhibitor with anti-tumor activity.
M3693 Daclatasvir dihydrochloride Daclatasvir is a potent hepatitis C virus (HCV) NS5A protein inhibitor with picomolar EC50 value .
M3680 GS-9451 GS-9451, a novel hepatitis C virus (HCV) nonstructural 3/4a (NS3/4a) protease inhibitor, is highly active in patients infected with HCV genotype 1 (GT 1).
M3666 Sofosbuvir (PSI-7977) Sofosbuvir (GS-7977) is an HCV RNA replication inhibitor with an EC50 of 92 nM.
M3630 BILN 2061 BILN 2061 is a specific and potent peptidomimetic inhibitor of the HCV NS3 protease with IC50 of 3.0 nM.
M3627 Vaniprevir Vaniprevir (MK-7009) is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease.
M3624 Boceprevir (EBP 520) Boceprevir (EBP-520, SCH503034) is an HCV protease inhibitor (Ki=14 nM) for the treatment of hepatitis C virus infection.
M3512 VX-222 VX-222 (VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L.
M3278 MK-5172 (Grazoprevir) MK-5172 is a novel NS3/4, a protease inhibitor for chronic HCV infection (Enzyme Ki for genotype1b, 2a, 2b and 3a at <0.02, 0.15, 0.02 and 0.7 nM, respectively).
M2727 GS-9256 GS-9256 is a novel phosphinic acid derived inhibitor of the HCV NS3/4A protease with IC50 of 4 nM.
M2554 TMC435350 TMC435350 is a highly specific and potent inhibitor of NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM).
M2553 GS-5885 GS-5885 is an inhibitor of the hepatitis C virus (HCV) NS5A protein and exhibits potent suppression of genotype 1 HCV replicons.

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