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HCV Protease HCV Protease


Cat.No.  Name Information
M21290 BMS-986144 BMS-986144 is a third generation pan-genotypic NS3/4A protease inhibitor.BMS-986144 inhibits GT-1a, GT-1b, GT-2a, GT-3a, 1a R155X, 1b D168V replicon with EC50 values of 2.3, 0.7, 1.0, 12, 8.0, 5.8 nM, respectively.BMS-986144 has the potential to study HCV infection.
M21285 AL-611 AL-611 is an HCV NS5B polymerase inhibitor (EC50 = 5 nM).
M21259 GSK2818713 GSK2818713 is an HCV NS5A replication complex inhibitor with an interesting biphenyl ligand.
M20732 Pibrentasvir (ABT-530) Pibrentasvir (ABT-530) is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with EC50 ranging from 1.4 pM to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6.
M20529 Glecaprevir Glecaprevir is a hepatitis C virus (HCV) nonstructural (NS) protein 3/4A protease inhibitor that targets the the viral RNA replication. It displays IC50 values ranging from 3.5 to 11.3 nM for clinical isolates of HCV genotypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, and 6a.
M20479 Tizoxanide Tizoxanide, a thiazolide anti-infective, is active against anaerobic bacteria, protozoa, and a range of viruses in cell culture models, and is currently in phase II clinical development for treating chronic hepatitis C.
M9758 Merimepodib Merimepodib, also known as VX-497, is an orally bioavailable IMPDH inhibitor with broad spectrum antiviral activities.
M9530 Inarigivir soproxil Inarigivir soproxil, also known as SB 9200, is a novel agonist of innate immunity, which shows potent antiviral activity against resistant HCV variants.
M8881 Ombitasvir Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a.
M8880 Paritaprevir Paritaprevir (ABT-450) is a potent non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50 values of 1 and 0.21 nM for HCV 1a and 1b, respectively.
M8217 BLT-1 Block lipid transport-1 (BLT-1) is a specific inhibitor of the SR-BI (Scavenger receptor, class B, type I) mediated lipid transfer.
M6191 Velpatasvir Velpatasvir is a second-generation NS5A inhibitor that inhibits hepatitis C viral replication through acting on the crucial "membranous web" that facilitates RNA replication.
M4691 Lycorine hydrochloride Lycorine hydrochloride is a natural alkaloid extracted from Amaryllidaceae (Amaryllidaceae) plants. It is a strong HCV inhibitor and melanoma angiogenesis inhibitor with anti-tumor activity.
M3693 Daclatasvir dihydrochloride Daclatasvir is a potent hepatitis C virus (HCV) NS5A protein inhibitor with picomolar EC50 value .
M3680 GS-9451 GS-9451, a novel hepatitis C virus (HCV) nonstructural 3/4a (NS3/4a) protease inhibitor, is highly active in patients infected with HCV genotype 1 (GT 1).
M3666 Sofosbuvir (PSI-7977) PSI-7977 (sofosbuvir) is an investigational nucleotide analog for treatment of chronic HCV infection.
M3630 BILN 2061 BILN 2061 is a specific and potent peptidomimetic inhibitor of the HCV NS3 protease with IC50 of 3.0 nM.
M3627 Vaniprevir Vaniprevir (MK-7009) is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease.
M3624 Boceprevir Boceprevir (EBP-520, SCH503034) is an HCV protease inhibitor (Ki=14 nM) for the treatment of hepatitis C virus infection.
M3512 VX-222 VX-222 (VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L.

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