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Vaniprevir

Cat. No. M3627
Vaniprevir Structure
Synonym:

MK-7009

Size Price Availability
10mM*1mL USD 405  USD450 Out of stock
5mg USD 351  USD390 Out of stock
10mg USD 495  USD550 Out of stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Vaniprevir (MK-7009) is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease. Vaniprevir is active against both the genotype 1 and genotype 2 NS3/4a protease enzymes. Vaniprevir (MK-7009) has good plasma exposure and excellent liver exposure in multiple species.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 757.95
Formula C38H55N5O9S
CAS Number 923590-37-8
Purity >98%
Solubility DMSO
Storage at -20°C
References

Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor.
McCauley JA, et al. J Med Chem. 2010 Mar 25;53(6):2443-63. PMID: 20163176.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Vaniprevir, MK-7009 supplier, HCV Protease, inhibitors

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