HCV Protease HCV Protease

Cat.No.	Name	Information
M2349	(R)-Nepicastat hydrochloride	(R)-Nepicastat hydrochloride, the R-enantiomer of Nepicastat hydrochloride, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.
M2340	Asunaprevir	Asunaprevir (BMS-650032) is a novel inhibitor of the hepatitis C virus enzyme serine protease NS3.
M2333	Dasabuvir (ABT-333)	ABT-333 is a nonnucleoside NS5B polymerase inhibitor for the treatment of HCV infection.
M2203	Elbasvir	Elbasvir (MK-8742) is an investigational HCV NS5A replication complex inhibitor.
M1843	BMS-790052	BMS-790052 (Daclatasvir) is a first-in-class, nonstructural protein 5A (NS5A) replication complex inhibitor with an EC50 of 9-50 pM.
M1808	Telaprevir	Telaprevir (VX-950) is a novel hepatitis C virus (HCV) NS3-4A protease inhibitor with IC50 of < 0.2 μM.
M53497	Hepatitis C Virus S5A/5B	Hepatitis C Virus S5A/5B is a synthetic peptide substrate.
M53496	Ac-D-DGla-LI-Cha-C	Ac-D-DGla-LI-Cha-C is a potent HCV protease inhibitor peptide.
M53495	Ac-EEVVAC-pNA	Ac-EEVVAC-pNA is a chromogenic substrate for a continuous spectrophotometric assay of HCV NS3 protease.
M53494	Hepatitis Virus C NS3 Protease Inhibitor 2	Hepatitis Virus C NS3 Protease Inhibitor 2 is a product-based peptide inhibitor of hepatitis C virus (HCV) NS3 protease, with a Ki of 41 nM.
M40946	Mipomersen	Mipomersen is a 20-base gapmer (antisense oligonucleotide) that inhibits apolipoprotein B (apoB) and lowers LDL, which can be used in studies related to hyperlipidemia. In addition, Mipomersen has anti-HCV activity.
M38751	Isoeuphorbetin	Isoeuphorbetin, a dimeric coumarin isolated from Viola philippica, is a potent HCV protease inhibitor with an IC50 of 3.63 µg/mL.
M28398	Grazoprevir sodium salt	Grazoprevir sodium salt (MK-5172 sodium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively. Grazoprevir sodium salt inhibits SARS-CoV-2 3CLpro activity.
M28219	Grazoprevir hydrate	Grazoprevir hydrate (MK-5172 hydrate) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively. Grazoprevir hydrate inhibits SARS-CoV-2 3CLpro activity.
M27943	Grazoprevir potassium salt	Grazoprevir potassium salt (MK-5172 potassium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively. Grazoprevir potassium salt inhibits SARS-CoV-2 3CLpro activity.
M21642	Voxilaprevir (GS-9857)	Voxilaprevir (GS-9857) is a noncovalent, reversible inhibitor of HCV NS3/4A protease inhibitor (PI) with pangenotypic antiviral activity. Voxilaprevir inhibits genotype 1b and 3a wild-type NS3 proteases with Ki values of 0.038 nM and 0.066 nM, respectively.
M21290	BMS-986144	BMS-986144 is a third generation pan-genotypic NS3/4A protease inhibitor.BMS-986144 inhibits GT-1a, GT-1b, GT-2a, GT-3a, 1a R155X, 1b D168V replicon with EC50 values of 2.3, 0.7, 1.0, 12, 8.0, 5.8 nM, respectively.BMS-986144 has the potential to study HCV infection.
M21285	AL-611	AL-611 is an HCV NS5B polymerase inhibitor (EC50 = 5 nM).
M21259	GSK2818713	GSK2818713 is an HCV NS5A replication complex inhibitor with an interesting biphenyl ligand.
M20479	Tizoxanide	Tizoxanide, a thiazolide anti-infective, is active against anaerobic bacteria, protozoa, and a range of viruses in cell culture models, and is currently in phase II clinical development for treating chronic hepatitis C.

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