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Elbasvir

Cat. No. M2203

All AbMole products are for research use only, cannot be used for human consumption.

Elbasvir Structure
Synonym:

MK-8742

Size Price Availability Quantity
5mg USD 95  USD95 In stock
10mg USD 150  USD150 In stock
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Quality Control & Documentation
Biological Activity

Elbasvir (MK-8742) is a hepatitis C virus nonstructural protein 5A (HCV NS5A) replication complex inhibitor, with EC50s of 4, 3 and 3 nM against genotype 1a, 1b, and 2a, respectively. Elbasvir has broad, potent HCV genotypic activity in vitro against viral variants that are resistant to other NS5A inhibitors. 

Chemical Information
Molecular Weight 882.02
Formula C49H55N9O7
CAS Number 1370468-36-2
Solubility (25°C) DMSO 45 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Lahser FC, et al. Antimicrob Agents Chemother. The Combination of Grazoprevir, a Hepatitis C Virus (HCV) NS3/4A Protease Inhibitor, and Elbasvir, an HCV NS5A Inhibitor, Demonstrates a High Genetic Barrier to Resistance in HCV Genotype 1a Replicons.

[2] Liu R, et al. Antimicrob Agents Chemother. Susceptibilities of genotype 1a, 1b, and 3 hepatitis C virus variants to the NS5A inhibitor elbasvir.

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Keywords: Elbasvir, MK-8742 supplier, HCV Protease, inhibitors, activators

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