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Lycorine hydrochloride

Cat. No. M4691
Lycorine hydrochloride Structure
Synonym:

Lycorine-chloride

Size Price Availability Quantity
20mg USD 72  USD80 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Lycorine hydrochloride is a natural alkaloid extracted from the Amaryllidaceae plant family, it is also an HCV inhibitor with strong activity. Lycorine HCl inhibits cell proliferation and induces cell apoptosis in acute myeloid leukemia (AML) cell line HL-60, monocyte leukemia cell line U937, and T-cell leukemia cell line Jurkat. Lycorine also blocks multiple myeloma KM3 cell cycle, induces K562 cell-cycle arrest at the G0/G1 phase and suppresses tumorigenesis and the growth of various tumor cells, including melanoma C8161, ovarian cancer Hey1B, lung cancer A549, glioblatatoma U373, and esophageal cancer OE21.

In vivo, Lycorine exhibits its numerous pharmacological effects on various diseases with very low toxicity and mild side effects. Lycorine hydrochloride effectively inhibits tumor growth in several mouse xenograft models. It effectively inhibits tumor neovascularization. Lycorine has trivial toxicity to normal cells and normal bodies. The animal toxicological experiments show that the 50% lethal death rate (LD50) of lycorine in mice is 112.2±0.024 mg/kg via intraperitoneal injection. The LD50 of lycorine in mice is 344 mg/kg via gastric lavage injection, suggesting that lycorine is very low toxicity in gastrointestinal administration.

Protocol
Cell Experiment
Cell lines K562 cells
Preparation method Briefly, nuclear proteins were extracted from K562 cells treated with different concentrations of lycorine (2.5 or 5.0 μM) or without lycorine for 24 h. About 50 μg of nuclear protein from each group was added to a 96-well tissue culture plate and HDAC enzymatic activities in the cell nucleus was determined according to the HDAC colorimetric assay kit instructions.
Concentrations 2.5 or 5.0 μM
Incubation time 24 h
Animal Experiment
Animal models SCID mice inoculated with HL-60 cells
Formulation dissolved in DMSO as a stock solution and then diluted in normal saline just prior to usage
Dosages 5 or 10 mg/kg/day
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 323.77
Formula C16H17NO4.HCl
CAS Number 2188-68-3
Purity >98%
Solubility DMSO: ≥ 30 mg/mL
Storage at -20°C
References

Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition.
Li L, et al. Cancer Cell Int. 2012 Nov 23;12(1):49. PMID: 23176676.

Treatment of lycorine on SCID mice model with human APL cells.
Liu J, et al. Biomed Pharmacother. 2007 May;61(4):229-34. PMID: 17336028.

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  Catalog
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Keywords: Lycorine hydrochloride, Lycorine-chloride supplier, HCV Protease, inhibitors

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