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Daclatasvir dihydrochloride

Cat. No. M3693
Daclatasvir dihydrochloride Structure
Synonym:

BMS790052 dihydrochloride

Size Price Availability Quantity
5mg USD 99  USD110 In stock
10mg USD 135  USD150 In stock
50mg USD 405  USD450 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Daclatasvir (DCV) is a potent hepatitis C virus (HCV) NS5A replication complex inhibitor with pangenotypic (1-6) activity in vitro. Daclatasvir inhibits the HCV nonstructural protein NS5A.Recent research suggests that it targets two steps of the viral replication process, enabling rapid decline of HCV RNA.Twelve or 16 weeks of treatment with daclatasvir, in combination with peginterferon alfa-2a and ribavirin, is well tolerated and effective therapy for patients with HCV genotype 2 or 3 infections. Daclatasvir-containing regimens could reduce the duration of therapy for these patients. Daclatasvir plus asunaprevir provided high sustained virological response rates in treatment-naive, non-responder, and ineligible, intolerant, or ineligible and intolerant patients, and was well tolerated in patients with HCV genotype 1b infection.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 811.80
Formula C40H52Cl2N8O6
CAS Number 1009119-65-6
Purity >98%
Solubility DMSO 148 mg/mL
Storage at -20°C
References

Evaluation of drug-drug interaction between daclatasvir and methadone or buprenorphine/naloxone.
Garimella T, et al. J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19628. PMID: 25394132.

Asymmetric Binding to NS5A by Daclatasvir (BMS-790052) and Analogs Suggests Two Novel Modes of HCV Inhibition.
Nettles JH, et al. J Med Chem. 2014 Nov 3. PMID: 25365735.

Daclatasvir plus Peginterferon and Ribavirin is Non-inferior to Peginterferon and Ribavirin Alone, and Reduces Duration of Treatment for HCV Genotype 2 or 3 Infection.
Dore GJ, et al. Gastroenterology. 2014 Oct 10;S0016-5085(14)01206-2.. PMID: 25311593.

All-oral daclatasvir plus asunaprevir for hepatitis C virus genotype 1b: a multinational, phase 3, multicohort study.
Manns M, et al. Lancet. 2014 Jul 26;S0140-6736(14)61059-X. PMID: 25078304.

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Keywords: Daclatasvir dihydrochloride, BMS790052 dihydrochloride supplier, HCV Protease, inhibitors

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