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Inarigivir soproxil

Cat. No. M9530
Inarigivir soproxil Structure

SB 9200

Size Price Availability Quantity
10mM*1mL USD 765  USD850 In stock
10mg USD 765  USD850 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Inarigivir soproxil shows potent antiviral activity against resistant hepatitis C virus (HCV) variants, with EC50s of 2.2 and 1.0 μM for HCV 1a/1b in cells of genotype 1 HCV replicon systems. Inarigivir soproxil has broad-spectrum antiviral activity against RNA viruses including hepatitis C virus (HCV), norovirus, respiratory syncytial virus, and influenza and has demonstrated activity against hepatitis B virus (HBV) in vitro and in vivo.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 703.62
Formula C25H34N7O13PS
CAS Number 942123-43-5
Purity >98%
Solubility DMSO ≥ 70 mg/mL
Storage at -20°C

SB 9200, a Novel Agonist of Innate Immunity, Shows Potent Antiviral Activity Against Resistant HCV Variants.
Meleri Jones, et al. J Med Virol. 2017 Sep;89(9):1620-1628. PMID: 28303593.

Antiviral Efficacy and Host Immune Response Induction During Sequential Treatment With SB 9200 Followed by Entecavir in Woodchucks.
Manasa Suresh, et al. PLoS One. 2017 Jan 5;12(1):e0169631. PMID: 28056062.

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Abmole Inhibitor Catalog 2017

Keywords: Inarigivir soproxil, SB 9200 supplier, HCV Protease, inhibitors

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