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Darunavir Ethanolate is an inhibitor of HIV protease. Darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including strains from treatment-experienced patients with multiple resistance mutations to PIs.
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Source | AAPS PharmSciTech (2017). Figure 7.Darunavir Ethanolate |
| Method | LC-MS method | |
| Cell Lines | Wistar rats | |
| Concentrations | 40 mg/kg | |
| Incubation Time | 0.5, 1, 2, 4, 8, and 24 h | |
| Results | The plasma concentration of darunavir in rats after oral administration of SLNs and peptide-grafted SLNs showed no significant difference (P > 0.5). |
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Source | AAPS PharmSciTech (2017). Figure 4.Darunavir Ethanolate |
| Method | Identification of Internalization Pathway | |
| Cell Lines | Caco-2 cell line | |
| Concentrations | ||
| Incubation Time | 0.5, 1, 2, 3, and 4 h | |
| Results | The relative uptake efficiency of darunavir in presence of endocytic inhibitors is graphically depicted in Fig. 4. |
| Cell Experiment | |
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| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
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| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 593.73 |
| Formula | C27H37N3O7S.C2H5OH |
| CAS Number | 635728-49-3 |
| Solubility (25°C) | DMSO ≥ 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Nguyen DN, et al. Int J Pharm. The fate of ritonavir in the presence of darunavir.
| Related HIV Protease Products |
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Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 is a fluorogenic substrate of HIV-1 protease. |
| Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2
Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 is a substrato peptídico of HIV-1 protease. |
| HIV-1, HIV-2 Protease Substrate
HIV-1, HIV-2 Protease Substrate is the substrate of HIV-1, HIV-2 protease. |
| HIV Protease Substrate IV
HIV Protease Substrate IV is a substrate of HIV protease. |
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