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Bevirimat

Cat. No. M1865

All AbMole products are for research use only, cannot be used for human consumption.

Bevirimat Structure
Synonym:

BVM, MPC-4326, PA-457

Size Price Availability Quantity
5mg USD 120  USD120 In stock
10mg USD 200  USD200 In stock
25mg USD 440  USD440 In stock
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Biological Activity

Bevirimat, the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients. Maturation inhibitors are an experimental class of antiretrovirals that inhibit Human Immunodeficiency Virus (HIV) particle maturation, the structural rearrangement required to form infectious virus particles. Unlike protease inhibitors, Bevirimat (BVM) blocks the cleavage of the Gag capsid precursor (CA-SP1) to mature capsid (CA) protein, resulting in the release of immature, noninfectious viral particles. Bevirimat specifically inhibits a single cleavage event, the final processing step for the Gag precursor where p25 (CA-SP1) is cleaved to p24 (CA) and SP1. The protease-dependent bevirimat resistance and replication levels can be explained by differences in CA/p2 cleavage processing by the different proteases.

Chemical Information
Molecular Weight 584.82
Formula C36H56O6
CAS Number 174022-42-5
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Dang et al. Bioorg Med Chem Lett. Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants.

[2] Nguyen et al. Retrovirology. The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particles.

[3] Dybowski et al. BioData Min. Improved Bevirimat resistance prediction by combination of structural and sequence-based classifiers.

[4] Fun et al. Retrovirology. HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat.

[5] Lu et al. Antimicrob Agents Chemother. A single polymorphism in HIV-1 subtype C SP1 is sufficient to confer natural resistance to the maturation inhibitor bevirimat.

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Keywords: Bevirimat, BVM, MPC-4326, PA-457 supplier, HIV Protease, inhibitors, activators

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