HIV Protease HIV Protease

Cat.No.	Name	Information
M2158	Lopinavir	Lopinavir (ABT-378) is a potent protease inhibitor.
M55542	Ritonavir-13c,d3	Ritonavir-13c,d3
M22445	Fosamprenavir	Fosamprenavir
M21645	Tipranavir	Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC50s of 66-410 nM.
M21426	BRD-K98645985	BRD-K98645985 is a mammalian SWI/SNF transcriptional repressor inhibitor with an EC50 of ~2.37 µM. BRD-K98645985 binds ARID1A-specific BAF complex, prevents nucleosome localization, effectively reverses HIV-1 latency, and has no T-cell toxicity.
M21114	Lenacapavir	Lenacapavir(GS-6207) is a first-in-class, long-acting HIV capsid inhibitor. Lenacapavir has anti-HIV activity with an EC50 of 100 pM in MT-4 cells and a mean EC50 of 50 pM (20-160 pM) against 23 clinical isolates of HIV-1 from different subtypes in peripheral blood mononuclear cells.
M19349	Hinokinin	Hinokinin (Cubebinolide) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme.
M13489	Nelfinavir	Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent.
M11497	Trilobatin	Trilobatin (P-phlorizin) is a natural flavonoid lipid molecule that is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope and has antioxidant and anti-inflammatory effects. Trilobatin is also an SGLT1/2 inhibitor that selectively induces human hepatoblastoma cell proliferation.
M11422	Sodium copper chlorophyllin B	Sodium Copper ch-ch-lin B has antiviral activity against both influenza virus and HIV with an IC50s of 50 to 100 μM.
M11185	3-Deazaadenosine hydrochloride	3-deazaadenosine HCl (3-DZA, c3Ado) is an effective s-adenosylhomocysteine hydrolase inhibitor with Ki value of 3.9 μM. 3-deazaadenosine HCl inhibits the transcription of TNF-α and IL-1β induced by bacterial liposolysaccharide. 3-deazaadenosine HCl inhibits NF-κB transcriptional activity, prevents CARBOxyl methylation of Ras induced by FCS, and reduces ERK1/2 and Akt phosphorylation induced by FCS.
M10758	ZL0580	ZL0580 is a structural analogue of ZL0590 that induces epigenetic suppression of HIV by selectively binding to the BRD4 domain of BD1. ZL0580 induces inhibition of HIV by inhibiting Tat transcriptional activation and transcriptional prolongation, as well as inducing inhibition of chromatin structures on an HIV promoter.
M10683	IMB-301	IMB-301 is a specific HIV-1 replication inhibitor that binds to hA3G (human APOBEC3G), interrupts the hA3G-Vif interaction and inhibits Vif-mediated degradation of hA3G. IMB-301 inhibits the replication of HIV-1 in H9 cells (IC50=8.63 uM). Human APOBEC3G is a restriction factor that inhibits human immunodeficiency 1 virus (HIV-1) replication.
M10371	Cabotegravir	Cabotegravir, also known as S/GSK1265744 or GSK744, is potent HIV integrase inhibitor.
M10364	Tenofovir hydrate	Tenofovir hydrate is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.
M10325	Diphyllin	Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM.
M10207	HIV-1 TAT Peptide TFA	TAT TFA is a cell-penetrating peptide which derived from the transactivator of transcription (TAT) of human immunodeficiency virus (HIV-1).
M9491	BMS-538203	BMS-538203 is a highly efficient HIV integrase inhibitor and antiviral agent.
M8972	BMS-626529	BMS-626529 is a potent HIV-1 attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells.
M6274	Tenofovir Disoproxil	Tenofovir dsoproxil is a nucleotide reverse transcriptase inhibitor.

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