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Sodium copper chlorophyllin B

Cat. No. M11422
Sodium copper chlorophyllin B Structure
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Biological Activity

Sodium Copper ch-ch-lin B has antiviral activity against both influenza virus and HIV with an IC50s of 50 to 100 μM.

Chemical Information
Molecular Weight 692.16
Formula C34H29CuN4NaO7(-2)
CAS Number 28302-36-5
Form Solid
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mohamed Abd Elfattah Noaishi, et al. Pak J Biol Sci. Comparative Toxicity Study of Novel Light-Activated Insecticide and Deltamethrin in Albino Rats

[2] Antonio Prez-Glvez, et al. Antioxidants (Basel). Carotenoids and Chlorophylls as Antioxidants

[3] Ana-Marija Domijan, et al. Food Chem. In vitro genotoxicity of mycotoxins ochratoxin A and fumonisin B(1) could be prevented by sodium copper chlorophyllin--implication to their genotoxic mechanism

[4] E Pimentel, et al. Mutat Res. A study of the inhibition/promotion effects of sodium-copper chlorophyllin (SCC)-mediated mutagenesis in somatic cells of Drosophila

[5] A A M Farag. Spectrochim Acta A Mol Biomol Spectrosc. Optical absorption of sodium copper chlorophyllin thin films in UV-vis-NIR region

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