BMS-663068 is the phosphonooxymethyl prodrug of BMS626529, a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells with EC50 of < 10 nM.
| Molecular Weight | 583.49 |
| Formula | C25H26N7O8P |
| CAS Number | 864953-29-7 |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Michael Kozal, et al. Fostemsavir in Adults with Multidrug-Resistant HIV-1 Infection
[2] Mary C Cambou, et al. Novel Antiretroviral Agents
[3] Ester Ballana, et al. BMS-663068, a safe and effective HIV-1 attachment inhibitor
| Related HIV Protease Products |
|---|
| Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2
Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 is a fluorogenic substrate of HIV-1 protease. |
| Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2
Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 is a substrato peptídico of HIV-1 protease. |
| HIV-1, HIV-2 Protease Substrate
HIV-1, HIV-2 Protease Substrate is the substrate of HIV-1, HIV-2 protease. |
| HIV Protease Substrate IV
HIV Protease Substrate IV is a substrate of HIV protease. |
| Herpes virus inhibitor 2
Herpes virus inhibitor 2 is a herpes virus inhibitor and disrupts herpes virus ribonucleotide reductase quaternary structure. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
