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BMS-663068

Cat. No. M2463
BMS-663068 Structure
Synonym:

Fostemsavir

Size Price Availability
5mg USD 360  USD400 1-2 Weeks
10mg USD 648  USD720 1-2 Weeks
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

BMS-663068 is the phosphonooxymethyl prodrug of BMS626529, a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells with EC50 of < 10 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 583.49
Formula C25H26N7O8P
CAS Number 864953-29-7
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BMS-663068, Fostemsavir supplier, HIV Protease, inhibitors

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