Salicylanilides are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.
|Solubility (25°C)||DMSO 30 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Steven Blake, et al. Salicylanilide Analog Minimizes Relapse of Clostridioides difficile Infection in Mice
 Jos A Marrugal-Lorenzo, et al. Repositioning salicylanilide anthelmintic drugs to treat adenovirus infections
 Jarmila Vinšov, et al. Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity
 A Atef El-Sayed, et al. Application of reactive salicylanilide to viscose fabrics as antibacterial and antifungus finishing
 Martin Krtk, et al. Salicylanilide ester prodrugs as potential antimicrobial agents--a review
|Poly-L-lysine (MW 15000~30000)
Poly-L-lysine (MW 15000~30000)
|Poly-L-lysine (MW 30000~70000)
Poly-L-lysine (MW 30000~70000)
GL67 (N4-Spermine cholesteryl carbamate) (pentahydrochloride) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection.
DRI-C21045 is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC50 of 0.17 µM. DRI-C21045 shows concentration-dependent inhibition of the activation of NF-κB and B cell proliferation all induced by CD40L with IC50s of 17.1 µM and 4.5 µM, respectively.
2-Naphthylacetic acid is a auxin which can promote plant growth.
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