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IMB-301 is a specific HIV-1 replication inhibitor that binds to hA3G (human APOBEC3G), interrupts the hA3G-Vif interaction and inhibits Vif-mediated degradation of hA3G. IMB-301 inhibits the replication of HIV-1 in H9 cells (IC50=8.63 uM). Human APOBEC3G is a restriction factor that inhibits human immunodeficiency 1 virus (HIV-1) replication.
| Molecular Weight | 379.26 |
| Formula | C19H17Cl2FN2O |
| CAS Number | 64009-84-3 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | -20°C |
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