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3-deazaadenosine HCl (3-DZA, c3Ado) is an effective s-adenosylhomocysteine hydrolase inhibitor with Ki value of 3.9 μM. 3-deazaadenosine HCl inhibits the transcription of TNF-α and IL-1β induced by bacterial liposolysaccharide. 3-deazaadenosine HCl inhibits NF-κB transcriptional activity, prevents CARBOxyl methylation of Ras induced by FCS, and reduces ERK1/2 and Akt phosphorylation induced by FCS.
| Molecular Weight | 302.72 |
| CAS Number | 86583-19-9 |
| Solubility (25°C) | DMSO 40 mg/mL Water ≥ 50 mg/mL |
| Storage | 4°C, dry, sealed |
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