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HIV-1 TAT Peptide TFA

Cat. No. M10207
HIV-1 TAT Peptide TFA Structure
Synonym:

HIV-1 tat Protein (47-57)

Size Price Availability Quantity
5mg USD 207  USD230 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

TAT TFA is a cell-penetrating peptide which derived from the transactivator of transcription (TAT) of human immunodeficiency virus (HIV-1).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 1673.85
Formula C66H119N32F3O16
CAS Number 191936-91-1 (free base)
Purity >99%
Solubility Water
Storage -20°C, sealed
References

Interaction of the protein transduction domain of HIV-1 TAT with heparan sulfate: binding mechanism and thermodynamic parameters
Andre Ziegler, et al. Biophys J. 2004 Jan;86(1 Pt 1):254-63. PMID: 14695267.

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Keywords: HIV-1 TAT Peptide TFA, HIV-1 tat Protein (47-57) supplier, HIV Protease, inhibitors

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