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Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC50s of 66-410 nM. Tipranavir also inhibits SARS-CoV-2 3CLpro activity. In Tipranavir/ritonavir-cotreated mice, the Tipranavir (PNU-140690) abundance in the liver, spleen, and eyes is significantly higher than that in mice treated with Tipranavir alone.
| Molecular Weight | 602.66 |
| Formula | C31H33F3N2O5S |
| CAS Number | 174484-41-4 |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] No authors listed. Tipranavir
[2] No authors listed. Tipranavir
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