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Tenofovir hydrate

Cat. No. M10364
Tenofovir hydrate Structure
Synonym:

GS 1278 hydrate; PMPA hydrate

Size Price Availability Quantity
10mM*1mL in DMSO USD 45  USD50 In stock
5mg USD 40.5  USD45 In stock
10mg USD 63  USD70 In stock
50mg USD 108  USD120 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tenofovir hydrate is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B. Tenofovir shows cytotoxic effects on cell viability in HK-2 cells, with IC50 values of 9.21 and 2.77 μM at 48 and 72 h in MTT assay, respectively. Tenofovir diminishes ATP levels in HK-2 cells. Tenofovir (3.0 to 28.8 μM) increases oxidative stress and protein carbonylation in HK-2 cells. Furthermore, Tenofovir induces apoptosis in HK-2 cells, and that apoptosis is induced via mitochondrial damage.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 305.23
Formula C9H16N5O5P
CAS Number 206184-49-8
Purity >98%
Solubility DMSO 5 mg/mL
Storage 2-8°C, sealed
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Keywords: Tenofovir hydrate, GS 1278 hydrate; PMPA hydrate supplier, HIV Protease, inhibitors

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