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Tenofovir hydrate is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B. Tenofovir shows cytotoxic effects on cell viability in HK-2 cells, with IC50 values of 9.21 and 2.77 μM at 48 and 72 h in MTT assay, respectively. Tenofovir diminishes ATP levels in HK-2 cells. Tenofovir (3.0 to 28.8 μM) increases oxidative stress and protein carbonylation in HK-2 cells. Furthermore, Tenofovir induces apoptosis in HK-2 cells, and that apoptosis is induced via mitochondrial damage.
| Molecular Weight | 305.23 |
| Formula | C9H16N5O5P |
| CAS Number | 206184-49-8 |
| Solubility (25°C) | DMSO 5 mg/mL |
| Storage | 2-8°C, sealed |
[2] James Riddell 4th, et al. JAMA. HIV Preexposure Prophylaxis: A Review
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