Free shipping on all orders over $ 500

Cabotegravir

Cat. No. M10371
Cabotegravir Structure
Synonym:

S/GSK1265744; GSK744

Size Price Availability Quantity
10mg USD 45  USD50 In stock
25mg USD 94.5  USD105 In stock
50mg USD 168.3  USD187 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Cabotegravir, also known as S/GSK1265744 or GSK744, is potent HIV integrase inhibitor. Cabotegravir is an inhibitor of OAT1 (IC50 0.81 μM) and OAT3 (IC50 0.41 μM).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 405.35
Formula C19H17F2N3O5
CAS Number 1051375-10-0
Purity >98%
Solubility DMSO 14 mg/mL
Storage at -20°C
References

The promise and pitfalls of long-acting injectable agents for HIV prevention
Raphael J Landovitz, et al. Curr Opin HIV AIDS. 2016 Jan;11(1):122-8. PMID: 26633643.

Disposition and metabolism of cabotegravir: a comparison of biotransformation and excretion between different species and routes of administration in humans
Gary David Bowers, et al. Xenobiotica. 2016;46(2):147-62. PMID: 26134155.

Related HIV Protease Products
Tenofovir hydrate

Tenofovir hydrate is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.

Diphyllin

Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM.

Diethyldithiocarbamate sodium

Sodium diethyldithiocarbamate is an accelerator of the rate of copper cementation. Sodium diethyldithiocarbamate reduces the incidence of HIV infection.

Apelin-36(rat, mouse) TFA

Apelin-36(rat, mouse) TFA is an endogenous orphan G protein-coupled receptor APJ agonist.

HIV-1 TAT Peptide TFA

TAT TFA is a cell-penetrating peptide which derived from the transactivator of transcription (TAT) of human immunodeficiency virus (HIV-1).

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Cabotegravir, S/GSK1265744; GSK744 supplier, HIV Protease, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.