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Ritonavir

Cat. No. M2159
Ritonavir Structure
Synonym:

ABT-538

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 37  USD37 In stock
10mg USD 54  USD54 In stock
50mg USD 125  USD125 In stock
100mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

Ritonavir is an HIV protease inhibitor used in the study of HIV infection and AIDS.

Chemical Information
Molecular Weight 720.94
Formula C37H48N6O5S2
CAS Number 155213-67-5
Solubility (25°C) DMSO 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zeldin RK, et al. J Antimicrob Chemother. Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIV-infected patients.

[2] Morissette SL, et al. Proc Natl Acad Sci U S A. Elucidation of crystal form diversity of the HIV protease inhibitor ritonavir by high-throughput crystallization.

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Keywords: Ritonavir, ABT-538 supplier, HIV Protease, inhibitors, activators


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