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Cat. No. M2225
Thalidomide Structure


Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 35  USD35 In stock
200mg USD 60  USD60 In stock
500mg USD 100  USD100 In stock
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Quality Control & Documentation
Biological Activity

Thalidomide is a sedative and immunomodulator used to study the symptoms of many cancers, it has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM.

Thalidomide (50 μg/mL) potentiates the anti-tumor activity of icotinib against the proliferation of both PC9 and A549 cells, and this effect is correlated with apoptosis and cell migration. In addition, Thalidomide and icotinib inhibits the EGFR and VEGF-R2 pathways in PC9 cells.

In vivo, Thalidomide (100 mg/kg, p.o.) inhibits the collagen deposition, down-regulates the mRNA expression level of α-SMA and collagen I, and significantly reduces the pro-inflammatory cytokines in RILF mice. Thalidomide alleviates RILF via suppression of ROS and down-regulation of TGF-β/Smad pathway dependent on Nrf2 status.

Product Citations
Chemical Information
Molecular Weight 258.23
Formula C13H10N2O4
CAS Number 50-35-1
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Takumi Ito, et al. Molecular mechanisms of thalidomide and its derivatives

[2] James E Ridings. The thalidomide disaster, lessons from the past

[3] Michael E Franks, et al. Thalidomide

[4] E Laffitte, et al. Thalidomide

[5] R J D'Amato, et al. Thalidomide is an inhibitor of angiogenesis

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Keywords: Thalidomide, Thalomid supplier, Ligand for E3 Ligase, inhibitors, activators

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