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Thalidomide

Cat. No. M2225
Thalidomide Structure
Synonym:

Thalomid

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 28  USD35 In stock
200mg USD 48  USD60 In stock
500mg USD 80  USD100 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Thalidomide is a sedative and immunomodulator used to study the symptoms of many cancers. Thalidomide inhibits E3 ubiquitin ligase, a CrBN-DDB1-Cul4A complex.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 258.23
Formula C13H10N2O4
CAS Number 50-35-1
Purity >98%
Solubility DMSO 30 mg/mL
Storage at -20°C
References

[1] Takumi Ito, et al. Molecular mechanisms of thalidomide and its derivatives

[2] James E Ridings. The thalidomide disaster, lessons from the past

[3] Michael E Franks, et al. Thalidomide

[4] E Laffitte, et al. Thalidomide

[5] R J D'Amato, et al. Thalidomide is an inhibitor of angiogenesis

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Keywords: Thalidomide, Thalomid supplier, TNF-alpha, inhibitors

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