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Ligand for E3 Ligase Ligand for E3 Ligase

Cat.No.  Name Information
M2225 Thalidomide Thalidomide is a sedative and immunomodulator used to study the symptoms of many cancers, it has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM.
M43913 2,6-Bis(benzyloxy)-3-bromopyridine 2,6-Bis(benzyloxy)-3-bromopyridine
M25473 HaloPROTAC3 HaloPROTAC3 is a conjugate of ligands for E3 and 16-atom-length linker, and it is also a highly potent and efficacious degrader of GFP-HaloTag7 fusion proteins with a DC50 of 19 nM.
M21003 CC-90009 CC-90009 is a first-in-class, novel Cereblon (CRBN) E3 ligase modulator that specializes in proteasomal degradation of GSPT1 (G1 to S phase transition 1).
M14863 CC-885 CC-885 is a regulator of CRBN protein with a wide range of strong CRBN-dependent anti-proliferative activity in various tumor cell lines, with enhanced anti-proliferative activity compared to lenalidomide and pomalidomide.CC-885 promotes the binding of CRBN to the novel substrate GSPT1, targeting its degradation.
M11441 CFT7455 CFT7455 is an orally active inhibitor of zinc finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3). CFT7455 is an anticancer agent that binds cereblon E3 ligase with high affinity (Kd 0.9 nM) (WO2022032132A1; Compound 1).
M10387 Thalidomide-NH-CH2-COOH Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein.
M9834 E3 ligase Ligand 4 E3 ligase Ligand 4 (Thalidomide 4-fluoride) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein, it can connect to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.
M9833 E3 ligase Ligand 3 E3 ligase Ligand 3 (Thalidomide-O-COOH) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein, it connected to the ligand for protein by a linker to form PROTACs.
M9832 E3 ligase Ligand 2 E3 ligase Ligand 2 (Thalidomide-4-OH) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein, it can be connected to the ligand for protein by a linker to form PROTACs.
M9826 E3 ligase Ligand 1 E3 ligase Ligand 1 (VHL ligand 2 hydrochloride; (S,R,S)-AHPC-Me hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.
M9736 VHL Ligand 1 hydrochloride VHL Ligand 1 hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.
M9033 VH-298 VH-298 is a potent VHL inhibitor that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, with a Kd value of 80 to 90 nM.
M1976 Pomalidomide Pomalidomide is the third-generation immunomodulatory agent, functions through interacting with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors. Pomalidomide is a second generation immunomodulator, TNF-α inhibitor with IC50 of 13 nM.
M43915 2,6-bis(benzyloxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2,6-bis(benzyloxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
M43914 2,6-Bis(benzyloxy)pyridine-3-boronic acid 2,6-Bis(benzyloxy)pyridine-3-boronic acid
M43912 2,6-bis(benzyloxy)pyridin-3-amine 2,6-bis(benzyloxy)pyridin-3-amine
M43910 3-[2,5-Difluoro-4-(4-piperidinyl)phenyl]-2,6-piperidinedione 3-[2,5-Difluoro-4-(4-piperidinyl)phenyl]-2,6-piperidinedione
M43905 2,6-Piperidinedione, 3-[4-(4-piperidinyl)phenoxy]- 2,6-Piperidinedione, 3-[4-(4-piperidinyl)phenoxy]-
M43904 2-Pyridinecarboxamide, N-(2,6-dioxo-3-piperidinyl)-5-(1-piperazinyl)- 2-Pyridinecarboxamide, N-(2,6-dioxo-3-piperidinyl)-5-(1-piperazinyl)-




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