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Ligand for E3 Ligase Ligand for E3 Ligase

Cat.No.  Name Information
M2225 Thalidomide Thalidomide is a sedative and immunomodulator used to study the symptoms of many cancers, it has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM.
M43913 2,6-Bis(benzyloxy)-3-bromopyridine 2,6-Bis(benzyloxy)-3-bromopyridine
M25473 HaloPROTAC3 HaloPROTAC3 is a conjugate of ligands for E3 and 16-atom-length linker, and it is also a highly potent and efficacious degrader of GFP-HaloTag7 fusion proteins with a DC50 of 19 nM.
M21003 CC-90009 CC-90009 is a first-in-class, novel Cereblon (CRBN) E3 ligase modulator that specializes in proteasomal degradation of GSPT1 (G1 to S phase transition 1).
M14863 CC-885 CC-885 is a regulator of CRBN protein with a wide range of strong CRBN-dependent anti-proliferative activity in various tumor cell lines, with enhanced anti-proliferative activity compared to lenalidomide and pomalidomide.CC-885 promotes the binding of CRBN to the novel substrate GSPT1, targeting its degradation.
M10387 Thalidomide-NH-CH2-COOH Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein.
M9834 E3 ligase Ligand 4 E3 ligase Ligand 4 (Thalidomide 4-fluoride) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein, it can connect to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.
M9833 E3 ligase Ligand 3 E3 ligase Ligand 3 (Thalidomide-O-COOH) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein, it connected to the ligand for protein by a linker to form PROTACs.
M9832 E3 ligase Ligand 2 E3 ligase Ligand 2 (Thalidomide-4-OH) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein, it can be connected to the ligand for protein by a linker to form PROTACs.
M9826 E3 ligase Ligand 1 E3 ligase Ligand 1 (VHL ligand 2 hydrochloride; (S,R,S)-AHPC-Me hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.
M9736 VHL Ligand 1 hydrochloride VHL Ligand 1 hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.
M9033 VH-298 VH-298 is a potent VHL inhibitor that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, with a Kd value of 80 to 90 nM.
M1976 Pomalidomide Pomalidomide is the third-generation immunomodulatory agent, functions through interacting with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors. Pomalidomide is a second generation immunomodulator, TNF-α inhibitor with IC50 of 13 nM.
M43915 2,6-bis(benzyloxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2,6-bis(benzyloxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
M43914 2,6-Bis(benzyloxy)pyridine-3-boronic acid 2,6-Bis(benzyloxy)pyridine-3-boronic acid
M43912 2,6-bis(benzyloxy)pyridin-3-amine 2,6-bis(benzyloxy)pyridin-3-amine
M43910 3-[2,5-Difluoro-4-(4-piperidinyl)phenyl]-2,6-piperidinedione 3-[2,5-Difluoro-4-(4-piperidinyl)phenyl]-2,6-piperidinedione
M43905 2,6-Piperidinedione, 3-[4-(4-piperidinyl)phenoxy]- 2,6-Piperidinedione, 3-[4-(4-piperidinyl)phenoxy]-
M43904 2-Pyridinecarboxamide, N-(2,6-dioxo-3-piperidinyl)-5-(1-piperazinyl)- 2-Pyridinecarboxamide, N-(2,6-dioxo-3-piperidinyl)-5-(1-piperazinyl)-
M43903 2,6-Piperidinedione, 3-[[6-(1-piperazinyl)-3-pyridinyl]amino]- 2,6-Piperidinedione, 3-[[6-(1-piperazinyl)-3-pyridinyl]amino]-




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