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E3 ligase Ligand 3

Cat. No. M9833

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E3 ligase Ligand 3 Structure
Synonym:

Thalidomide-O-COOH; Cereblon ligand 3

Size Price Availability Quantity
50mg USD 100  USD100 In stock
100mg USD 150  USD150 In stock
250mg USD 250  USD250 In stock
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Quality Control & Documentation
Biological Activity

E3 ligase Ligand 3 (Thalidomide-O-COOH) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein, it connected to the ligand for protein by a linker to form PROTACs.

Chemical Information
Molecular Weight 332.26
Formula C15H12N2O7
CAS Number 1061605-21-7
Solubility (25°C) DMSO 35 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Mikołaj Słabicki, et al. Small-molecule-induced polymerization triggers degradation of BCL6

[2] Kalliopi Tzavlaki, et al. TGF-β Signaling

[3] Chaojun Yan, et al. PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis

[4] Jun Araya, et al. PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis

[5] Morgan S Gadd, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation

Related Ligand for E3 Ligase Products
OICR-8268

OICR-8268 is a reversible DCAF1 ligand that binds to the DCAF1 WDR domain with a Kd of 38 nM. OICR-8268 can be used in the development of DCAF1-based PROTACs.

BC-1215

BC-1215 is a novel inhibitor of F-box protein 3 (Fbxo3) activity. BC-1215 works by antagonizing of Fbxo3 on TRAF cytokine signaling and exhibits a low IC50 in vitro. BC-1215 relieves allodynia by preventing ubiquitination-dependent Fbxl2/TRAF2/TNIK/pGluR1 signaling. BC-1215 exerted robust therapeutic effects in cytokine-driven inflammation, including pseudomona-induced lung injury and cecum ligation/punctured-induced sepsis, by targeting Fbxo3/Fbxl2/TRAF-mediated cytokine release. BC-1215 can be used for the research of inflammation.

VH 101, acid 

VH 101, acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development.

(S,R,S)-AHPC-Boc

(S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.

Lenalidomide-Br 

Lenalidomide-Br is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein.

  Catalog
Abmole Inhibitor Catalog




Keywords: E3 ligase Ligand 3, Thalidomide-O-COOH; Cereblon ligand 3 supplier, Ligand for E3 Ligase, inhibitors, activators

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