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E3 ligase Ligand 3

Cat. No. M9833
E3 ligase Ligand 3 Structure

Thalidomide-O-COOH; Cereblon ligand 3

Size Price Availability Quantity
50mg USD 100  USD100 In stock
100mg USD 150  USD150 In stock
250mg USD 250  USD250 In stock
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Quality Control & Documentation
Biological Activity

E3 ligase Ligand 3 (Thalidomide-O-COOH) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein, it connected to the ligand for protein by a linker to form PROTACs.

Chemical Information
Molecular Weight 332.26
Formula C15H12N2O7
CAS Number 1061605-21-7
Solubility (25°C) DMSO 35 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Mikołaj Słabicki, et al. Small-molecule-induced polymerization triggers degradation of BCL6

[2] Kalliopi Tzavlaki, et al. TGF-β Signaling

[3] Chaojun Yan, et al. PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis

[4] Jun Araya, et al. PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis

[5] Morgan S Gadd, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation

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Keywords: E3 ligase Ligand 3, Thalidomide-O-COOH; Cereblon ligand 3 supplier, Ligand for E3 Ligase, inhibitors, activators

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